The D-backs prospect allowed one run on five hits over 4 1/3 innings, pitching the first-place Salt River Rafters to a 2-1 victory over the Peoria Javelinas.
After yielding 12 runs -- 10 earned -- on 16 hits over his first 9 2/3 innings, Brewer (1-0) registered his first win in four outings. The 23-year-old right-hander struck out six and walked one.
Selected in the 12th round of the 2009 Draft, Brewer went 5-1 with a 2.58 ERA in 11 starts for Double-A Mobile, fanning 48 over 52 1/3 innings. He allowed one earned run or fewer in six of his final seven starts after missing two months with a fractured wrist.
Dodgers prospect Josh Wall notched his league-leading third save with a perfect ninth.
The Rafters were led offensively by fellow Arizona prospect Ryan Wheeler and Tim Wheeler (Rockies), who combined to knock in both runs. Ryan Wheeler hit a two-out single in the first to score Adam Eaton (Rangers), while Tim Wheeler launched a leadoff homer in the third that proved decisive.
Brewers outfielder Kentrail Davis provided Peoria's offense with a two-out homer in the second. Matt Adams (St. Louis) and Logan Schafer (Brewers) both collected three hits for the Javelinas, who have lost two in a row.
Mets prospect Collin McHugh (1-2) took the loss after yielding two runs on five hits over three innings.
Seven relievers -- three from Peoria and four from Salt River -- combined to hurl 9 2/3 scoreless innings.
David Heck is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.