Wang faced the minimum until J.D. Drew connected for a solo homer in the fifth inning, when the ball tipped off Bobby Abreu's glove in right field and landed in the Red Sox's bullpen. Unrattled, Wang cruised the rest of the way, allowing only Coco Crisp's bunt single with two outs in the ninth before finishing his masterpiece.
"I feel especially good about this one because I threw the ball very good here in Boston," Wang said, noting the Yankees' rivalry with their classic American League East foes.
Wang has flirted with perfection before, most recently falling five outs shy of a perfect game last May against the Mariners. The Red Sox have given Wang trouble, however, as batters usually dig in and sit on his bowling-ball sinker. Partially with Boston in mind, Wang focused this spring on expanding his repertoire to keep hitters honest and move them off the plate.
"He's worked very hard at making his slider better, his changeup and his split," Yankees manager Joe Girardi said. "It starts with the sinker, like it always did. When you have a couple of different pitches to go to, he got some strikeouts with some sliders, and it helps. Then they can't sit on one area or one pitch."
"He was electric tonight," said Jason Giambi, who homered for New York. "You could tell the ball was moving a lot. He looked comfortable, and he threw a lot of strikes. Boston is almost the exact mirror team -- guys take a lot of pitches and do a lot of damage by taking walks and hitting home runs. I think he just pounded the strike zone so much that it caught them off guard."
Mixing his pitches and creating more fly-ball outs (14) than usual, Wang retired the first 10 batters before Dustin Pedroia chopped a hard shot down the third-base line in the fourth inning. Alex Rodriguez made a stab but was charged with a throwing error on a questionable scoring decision.
David Ortiz, batting .500 (15-for-30) against Wang coming into the game, then grounded into a 5-4-3 double play, keeping Wang's no-hit bid intact. Ortiz finished 0-for-3, as did Manny Ramirez, who had punished Wang to a .591 (13-for-22) mark.
"I was hoping he got a no-hitter, so I didn't really care," Rodriguez said. "Obviously, I thought it was a hit, but any questionable call, I was hoping they'd give him an error. I didn't want to be responsible for history."
With Wang cruising, the Yankees scored the first run of the 18-game regular-season slate between the rivals in the fifth inning, as Molina touched right-hander Clay Buchholz with the first of his two doubles, scoring Hideki Matsui.
Given the lead, Wang saw his mechanics get a little sloppy in the fifth. Ramirez and Kevin Youkilis flied out to deep right for the first two outs of the inning, but Drew launched a deep drive that Abreu appeared to have a bead on. Abreu jumped at the wall but jarred his right shoulder against the fence, tipping the ball into the Boston bullpen and spoiling the no-hit bid.
"I felt bad," Abreu said. "It could have been a chance to no-no there. We try to do the best we can do."
Wang would recover, getting Jason Varitek to fly loudly to center before pitching coach Dave Eiland corrected a flaw in Wang's mechanics, telling him to get more on top of his pitches. Armed with that, Wang retired the next 11 before Crisp reached on his two-out bunt in the ninth. Pedroia flied out to left for the final out, and Wang's two-hitter was complete.
"I had good defense catching the ball for me," Wang said. "I could control the ball inside and outside today. Sometimes the slider would run, but the sinker was good."
"When you have a sinker like he does, and you're throwing it down like he was tonight, not many people are going to hit it," Molina said.
In the fifth, Buchholz walked three and surrendered Molina's run-scoring double, but the right-hander escaped when Melky Cabrera lined to first for a double play. Facing the Yankees for the first time in his career, Buchholz walked three and struck out three, leaving after six innings tied in an eventual no-decision.
Tied at 1 with the defending World Series champs after six innings, the Yankees took the lead in the seventh when Giambi -- with just one hit in 15 at-bats before Friday -- greeted reliever Mike Timlin with a solo home run, just over the 379-foot mark in left-center field.
The ball hit near a television camera platform as Crisp waited for a rebound bounce that never came. Later in the inning, Molina stroked his second double of the game, moved up on a bunt and then scored on Cabrera's sacrifice fly, providing a healthy cushion to help back Wang's economical 93-pitch effort.
"The team looks awfully good when a guy can go out there and throw nine innings and be great," Rodriguez said.
Rodriguez, Matsui and Molina each had two hits for New York, who added a run in the ninth on Abreu's broken-bat infield single. The Red Sox and Yankees will meet 17 more times this season, including twice more as they complete the weekend series in Boston.