Nixon, who had never played first in 1,081 career big league games, was signed by the D-backs just prior to the reporting date for position players as insurance in case backup first baseman Chad Tracy was not going to be ready for Opening Day.
Arizona manager Bob Melvin wanted to ease Nixon into the position, so he sent him over to Minor League camp on Thursday. The plan was to have him play there again before getting into a Cactus League game, but Nixon told Melvin he was ready on Friday.
It was just one inning, but thanks to a three-run inning by the Giants, Nixon had plenty of time to work on cutoffs and holding runners on.
"It was a good experience and I'll just build off that," Nixon said.
"For an uncomfortable position, he seemed fairly comfortable," Melvin said.
Steve Gilbert is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.