An article in The San Francisco Chronicle had linked the 37-year-old Byrd to the Palm Beach Rejuvenation Center in Florida, where he reportedly bought nearly $25,000 worth of HGH and syringes between August 2002 and January 2005.
At the time, Byrd was with the Royals, Braves and Angels. Byrd didn't sign with the Indians until the winter before the '06 season.
His meeting with baseball officials had been expected. When The Chronicle story broke, Byrd stressed that he never took any drug that a doctor didn't prescribe.
"I have a reputation, I speak at different places, I speak to kids, I speak to churches," he told reporters before the ALCS game. "I do not want the fans in Cleveland -- I do not want honest, caring people -- to think that I cheated, because I didn't.
"That is very important to me."
In an interview with FOXSports.com, Byrd said three doctors had diagnosed him as suffering from a deficiency of adult-growth hormone. He also said he had been diagnosed with a tumor on his pituitary gland at the base of his brain in Spring Training of this year.
Byrd told FOXSports that he no longer uses HGH. He was less forthcoming about HGH in his interview with other media.
"That's a private matter right now with me," he said of his reported HGH use. "I do still have a pituitary issue. I don't know exactly what that means. I'm still learning about that. I will have to get tested for a while now. And that changes a lot of things for me. I don't know what the future holds for me."
Nor does anybody else just yet.
After issuing the 311-page report, former U.S. Sen. George Mitchell, who authored the document, called for no penalties for the men named in it. Last week, Commissioner Bud Selig said he would deal with the players named on a "case-by-case basis." Speaking at a scholarship/awards luncheon in Cleveland on Tuesday, Selig said he was not prepared to go beyond what he'd said last Thursday about the Mitchell Report.
Selig did tell reporters he had reread the Mitchell report and was now studying and analyzing issues that grew out of it.
Indians general manager Mark Shapiro declined to comment on Byrd's meeting with MLB.