Kershaw, Cueto clash in finale on MLB.TV

LA ace's last loss was vs. Giants, but he has a career 1.66 ERA against them

Kershaw, Cueto clash in finale on MLB.TV

Three-time Cy Young Award winner Clayton Kershaw looks to continue his dominance over the division-rival Giants as the Dodgers try to secure the series finale in San Francisco this afternoon, streaming live on MLB.TV.

Kershaw has faced the Giants twice already this season, tossing seven innings of one-run ball in a win against them on April 25 and allowing four runs (three earned) in six frames in a loss versus San Francisco on May 1.

Though Kershaw lost to the Giants his last time facing them, he has put up remarkable numbers against the Dodgers' National League West foe throughout his career. The southpaw is 19-9 with a 1.66 ERA in 38 games (37 starts) when matched up against San Francisco, while compiling 290 strikeouts in 276 1/3 innings.

The Giants will counter Kershaw with right-hander Johnny Cueto, who has beaten Los Angeles once in two starts this season. First pitch is scheduled for 3:45 p.m. ET (12:45 p.m. PT).

MLB.TV Premium is available for $112.99 yearly or $24.99 monthly, with nearly two dozen features for subscribers to access and interact with live out-of-market Major League Baseball games at 60 frames per second on any of the more than 400 supported devices. MLB.TV Single Team subscriptions are also available at $87.49 yearly.

Here's what else to watch for throughout the day (all times in ET):

Making the leap: HOU@MIA, 12:10 p.m.

Marlins right-hander Jose Urena worked 15 1/3 innings of relief this season before he was promoted to the rotation May 7. The 25-year-old has looked the part so far, completing six innings in each of his two starts, and going 1-1 with a 1.50 ERA.

Urena struggled when given chances to start in 2015 and '16, but he's yet to waver this season. Perhaps he is finally ready to solidify his role as a starter.

Urena K's four over six frames

Urena will attempt to keep rolling opposite Astros' righty Lance McCullers Jr., who is off to a fine first month-and-a-half. McCullers is 3-1 with a 2.98 ERA in eight starts for Houston.

Wins aplenty: COL@MIN, 8:10 p.m.

Twins righty Ervin Santana is one of the main reasons Minnesota enters play on Wednesday with one of the best records in the American League. Santana has one subpar outing this year, a May 7 loss to the Red Sox during which he surrendered six runs in six innings.

Nearly every other start has been flawless. It's why he's 6-1 with a minuscule 1.50 ERA through eight starts. The 34-year-old has completed at least six innings in each start, and gone at least seven in half of them.

Santana's scoreless gem

Santana looks to continue his winning ways versus the surprising Rockies and German Marquez, who is coming off the best start of his young career. The 22-year-old Marquez fired eight scoreless innings, giving up just three hits and a walk while striking out eight in a win over the Cubs his last time out.

ERA king takes the hill: NYY@KC, 8:15 p.m.

Who would have guessed at this point in the season that the Royals' Jason Vargas would be leading the Majors in ERA? No one has been better in keeping runs off the scoreboard than Vargas, who is 5-1 with a 1.01 ERA to date.

Vargas tosses seven scoreless

Vargas will have his hands full with a potent Yankees lineup and right-hander Michael Pineda toeing the rubber on the other side. Pineda is 3-2 with a 3.27 ERA in what has been a very solid start to 2017.

Sea of red: BOS@STL, 8:15 p.m.

The Red Sox and Redbirds go head-to-head Wednesday night with reigning AL Cy Young Award winner Rick Porcello getting the ball opposite Mike Leake, who is among the MLB leaders with a 1.94 ERA.

Porcello gets Rasmus swinging

Porcello has settled in after a rough start to the year with quality starts in each of his last five. Leake has been incredibly consistent, with a quality start in each of his seven outings. He's been a big part of the Cardinals' early-season success.

Oliver Macklin is a reporter for MLB.com based in Washington, D.C. This story was not subject to the approval of Major League Baseball or its clubs.