DENVER -- Padres starter Luis Perdomo was scratched from Wednesday's start due to right shoulder inflammation, and he will go on the disabled list, according to manager Andy Green. Zach Lee will start in Perdomo's place in the rubber match with the Rockies.
"He's got posterior shoulder inflammation," Green said. "Our perspective is it's not severe, but [the move is] more precautionary. It's hard to put a timetable on something like this. We're very hopeful he doesn't miss many starts."
Right-hander Jake Esch will be recalled from Double-A San Antonio on Wednesday, and he will presumably take Lee's role as the long man in the bullpen.
Perdomo had experienced discomfort for more than a week, but he just brought it to the Padres' attention a few days after his first start of the season -- a 5 1/3-inning outing against the Giants in which he allowed five runs on seven hits and a walk in Friday's home opener.
"He started to feel it in his bullpen session, and he had a thorough exam [Tuesday]," Green said. "We thought this was the best course of action. He had a little bit of something that he wasn't talking about after his last outing in Spring Training. He made us aware after his bullpen session two days ago."
Perdomo spent three full seasons in rookie ball and Class A before moving to the Padres' pitching staff at the start of 2016. He ended up leading San Diego starters in wins (nine) and innings (146 2/3) last year.
Lee was initially called up with the possibility of starting Monday in place of Trevor Cahill, who went on the DL with a lower-back strain. He will be making his second big league appearance after having one start with the Dodgers in 2015.
"It's exciting," Lee said upon hearing the news Tuesday night. "I kind of knew that was a possibility when I got called up, to an extent. Really, I was just preparing for whatever role they had me in. Just the way it got planned out, I'd be the long guy for a couple days. I got prepared mentally for that, and now I've got to prepare for the first start."
Lee, 25, was the Dodgers' 2013 and 2015 Branch Rickey Minor League Pitcher of the Year, and he earned several call-ups in '15, when he went 11-6 with a 2.70 ERA in 19 starts for Triple-A Oklahoma City in the offensive-oriented parks of the Pacific Coast League.
Lee's lone appearance in the Majors was a July 25, 2015, start against the Mets. He gave up seven earned runs on 11 hits and a walk over 4 2/3 innings in a loss.
Owen Perkins is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.