Sale, who was traded from the White Sox to the Red Sox this offseason, faces Boston's longtime rival, the Yankees, for the first time this spring. It will be the 27-year-old's fourth start of 2017 Spring Training as he continues to gear up for pitching in the American League East.
Cruz, Cano and Segura competed for the Dominican Republic in the World Baseball Classic, but they are scheduled to return to Seattle's spring complex in Peoria, Ariz., following the Dominican team's elimination Saturday with a 6-3 loss to Team USA.
Classic play reaches the semifinal round in Los Angeles on MLB.TV, where fans can follow much of this spring's action.
MLB.TV Premium is only $112.99 for the entire season. In addition to getting every out-of-market game live or on demand during the regular season, you can watch nearly 300 Spring Training games live and blackout free, plus the World Baseball Classic live (U.S. only). This package has the best value and provides access to more than 400 devices and a free subscription to the MLB.com At Bat Premium app (a $19.99 value). It offers the best picture quality ever -- at 60 frames per second -- for supported devices, while other great features include choice of home or away broadcasts, live game DVR, multi-game viewing and more. Monthly signups for MLB.TV Premium are now underway as well for $24.99, and the MLB.TV Single Team package is also available as an $87.49 yearly subscription.
Here's what to watch for throughout the day (all times ET):
Sale takes on Bronx Bombers: BOS@NYY, 6:35 p.m., MLB.TV
Sale returns to the mound for the first time since Thursday, when he allowed three earned runs and seven hits in four innings vs. the Pirates.
The lanky lefty said he didn't "feel as sharp" during the meeting with Pittsburgh as he did in his prior outing, when he gave up just one hit and a walk over four scoreless innings in a win over the Rays.
Overall, Sale has been solid this spring, going 1-0 with a 3.60 ERA in three starts. He'll look to get back to his winning ways against Gary Sanchez and the Yankees, whose 35 homer runs this spring are second only to the Brewers' 37.
The Dominican trio returns: OAK@SEA, 10:10 p.m., MLB.TV
Cruz, Cano and Segura were unable to lift the Dominican Republic into the WBC '17 semifinals, so now they will head back to their big league club. Cruz hit .300 with three homers and five RBIs; Cano hit .300 with a homer, a double and three RBIs; and Segura hit .364 with two doubles, a stolen base and three RBIs during the Dominican's run to the second round of the Classic.
"They're ready to go, obviously," Mariners manager Scott Servais said of his returning stars. "They're ready to start the season tomorrow if you could. I'm sure they'd prefer it that way."
Servais is certainly ready to get one-third of his Opening Day lineup back.
"Hopefully we'll get the guys back in here, and back into the routine," Servais said. "Obviously these [Classic] games are high-intensity and very emotional, but I think it's important to get our guys back into a routine and in our clubhouse and ready to go."
Ryu looking to build on strong start: MIL@LAD, 4:05 p.m., MLB.com Radio
The Dodgers' Hyun-Jin Ryu, who has made just one start during the past two seasons because of a shoulder injury, has looked good this spring in limited action.
Ryu has allowed one run in five innings in two Cactus League starts. The left-hander finished fourth in the National League Rookie of the Year Award voting in 2013, and he was an important piece of the Dodgers' rotation in both '13 and '14.
Ryu, fully healthy and inching closer to pre-injury form, is looking to earn a spot on the club's Opening Day roster. Manager Dave Roberts says Ryu will try to complete four innings against the Brewers.
Oliver Macklin is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.