The Rays' offense -- which featured 23 hits on the afternoon -- got into gear in the second inning when Nick Franklin and Curt Casali each had two-run homers off Twins starter Hector Santiago. Franklin and Casali are involved in competitive battles this spring for the utility and catching duties, respectively.
Jake Bauers' double down the right-field line chased Santiago. Evan Longoria added an RBI single off Randy Rosario to complete the scoring in the five-run frame. All of the runs were charged to Santiago, who did not record an out in the second.
Santiago, who is slated to join Team Puerto Rico in the World Baseball Classic, will have one more start before departing Twins camp.
"I wish I could've got through two and got the six outs, but I think all around, some good stuff," Santiago said. "Some good screwballs, some good curveballs. The fastball command was OK. I was 3-0 to the first guy, but I battled back and got out of that inning after the leadoff double."
The Rays celebrated their five-run second with an eight-run third. Bauers hit a grand slam off Tyler Duffey, and Rickie Weeks added a three-run homer off Felix Jorge to push the lead to 13-0.
Cade Gotta delivered a three-run homer in the sixth to give the Rays a 16-0 lead.
"It's good for us as a team, and we're doing a pretty good job, we're scoring a lot of runs this spring," Franklin said. "It's great. It's early. But we want to keep pouring it on. Keep it going."
Alex Cobb made his first start of the spring for the Rays and retired the six batters he faced during his two-inning stint that included two strikeouts.