In their absence, Yost will get to see several young catchers, such as Cam Gallagher, Parker Morin, Zane Evans and Chase Vallot, as well as veteran Brayan Pena, a non-roster invitee.
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Prospects Hunter Dozier and Ryan O'Hearn will get looks at first base while Hosmer is away.
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"Our young catchers wouldn't have an opportunity to play very much, because we'd be trying to get Drew [Butera] ready and Sal [Perez] ready," Yost said. "So we get to see our young first basemen and then see our younger shortstops like [Ramon] Torres and [Humberto] Arteaga.
"From that perspective, it's not a bad thing."
Yost will admittedly miss his key players, but he is supportive of their decision to take part in the Classic.
"I mean, do I want my players to go play the WBC? Nah, I'd rather have them here," Yost said. "But is it a cool thing to go play the WBC? Yeah, it's great to play for your country. I'd want to if I was a player."
Jeffrey Flanagan has covered the Royals since 1991, and for MLB.com since 2015. Follow him on Twitter @FlannyMLB. This story was not subject to the approval of Major League Baseball or its clubs.