The players listed below are in position to provide difference-making stats for DraftKings participants on Saturday.
Carlos Gonzalez: In his career, the outfielder has fared best against right-handers (.925 OPS) and at his hitter-friendly home park (1.011 OPS). CarGo could post a difference-making DraftKings total when he hits at Coors Field against Brewers righty Wily Peralta (career 4.22 ERA, 1.42 WHIP).
Charlie Blackmon: Like his teammate Gonzalez, Blackmon has excelled against right-handers (lifetime .829 OPS) and at his offense-inducing home park (lifetime .892 OPS). Hitting leadoff, the outfielder may maximize his opportunities to reach base and score runs against the right-handed Peralta (5.10 ERA, 1.56 WHIP in 2016), who in his career has allowed left-handed hitters such as Blackmon to post an .821 OPS (.709 OPS allowed to righty batters).
Miguel Cabrera: With a lofty lifetime .322/.389/.563 slash line against right-handers, the first baseman has the skills to post a substantial DraftKings total when he faces Braves rookie righty Aaron Blair (8.02 ERA, 1.73 WHIP).
Cameron Maybin: With a lifetime .708 OPS against right-handers that exceeds his .666 mark vs. lefties, the outfielder could reach base often against the rookie righty Blair (6.52 FIP). Maybin could also swipe his 16th base of the season against catcher Tyler Flowers, who has thwarted three of 63 would-be basestealers in 2016.
Brian Dozier: Having compiled 42 homers across 608 at-bats, the second baseman has been the most powerful player at his premium position this season. Dozier could go deep when he bats at homer-happy U.S. Cellular Field against fly-ball-prone righty James Shields (5.82 ERA, 2.0 HR/9 rate in 2016).
Anthony Rizzo: With 32 homers, 106 RBIs and 92 runs across 665 plate appearances, the first baseman has been one of the most productive players in baseball this season. From the heart of a Cubs lineup that ranks third in baseball with 790 runs scored, Rizzo could post a substantial DraftKings total at the expense of rookie righty Tim Adleman (5.53 FIP) and a Reds relief corps that ranks 29th in baseball with a 5.02 ERA.
Addison Russell: The second-year shortstop will be in prime position to improve on his lifetime 97 wRC+ against right-handers (81 vs. lefties) when he and his talented teammates face the rookie righty Adleman and an unreliable Reds bullpen.
Brad Miller: Eligible at first base and shortstop in DraftKings contests, Miller could enter lineups in multiple ways when he takes his lifetime .206 ISO against right-handers (.094 vs. lefties) into a matchup against righty Colby Lewis (career 4.73 ERA, 1.35 WHIP) at hitter-friendly Globe Life Park in Arlington. With 30 homers across 541 at-bats, Miller has made major improvements to his power stroke this season.
Corey Dickerson: With 23 homers across 497 at-bats this season and an impressive lifetime .887 OPS against right-handers (.655 vs. lefties), the outfielder is a strong candidate to rip a roundtripper when he vacates his pitcher-friendly home park and bats at Texas' offense-inducing venue against the right-handed Lewis and a Rangers relief corps that ranks 25th in the Majors with a 4.40 ERA.
Todd Frazier: With 40 homers and 98 RBIs across 578 at-bats, the third baseman has been one of the most powerful players in the American League this season. Frazier could go deep or drive in multiple runs when he brings his lifetime .833 OPS against left-handers (.766 vs. righties) into a matchup with southpaw Hector Santiago (4.87 ERA, 1.38 WHIP in 2016) and a Twins bullpen that ranks 26th in baseball with a 4.64 ERA.
Paul Goldschmidt: With a lifetime .336/.440/.600 slash line against left-handers, the first baseman has proven to be one of the best during those matchups. Goldschmidt could post a substantial DraftKings total when he works at his hitter-friendly home park against lefty Clayton Richard (career 4.21 ERA, 1.41 WHIP) and a Padres bullpen that ranks 22nd in baseball with a 4.12 ERA.
Hisashi Iwakuma: The right-hander could improve on his second-half 3.56 ERA when he works at his pitcher-friendly home park against an A's lineup that ranks 27th in the Majors with a .700 OPS against righties.
Jon Lester: With a 2.28 ERA and a 1.00 WHIP, the left-hander has been one of the most effective starters in the National League this season. Lester could continue to limit the opposition when he tangles with a Reds lineup that ranks 25th in the Majors with a .697 OPS against southpaws.
Clayton Kershaw: Having posted a 1.87 ERA and a 0.86 WHIP since the outset of 2013, the left-hander is the consensus choice as the most dominant starter in baseball. Kershaw could post a game-changing DraftKings total when he works at pitcher-friendly AT&T Park against a Giants lineup that ranks 23rd in the Majors with a .710 OPS against southpaws.
Bartolo Colon: Having posted a 3.42 ERA, the right-hander has been one of the most reliable starters in the National League this season. Colon could compile a handful of effective innings when he faces a Phillies lineup that ranks 29th in the Majors with a .692 OPS against righties.
All statistics are accurate through the completion of Thursday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.