The players listed below are in position to provide difference-making stats for DraftKings participants on Friday.
Trea Turner: During his impressive rookie season, Turner has produced a .973 OPS against right-handers in comparison to a .696 mark vs. lefties. The outfielder could post a game-changing DraftKings total when he faces Marlins righty Andrew Cashner, who has produced a 4.66 ERA and a 1.47 WHIP since the outset of last season.
Robinson Cano: Hitting .299 with 36 homers and 97 RBIs across 639 at-bats, the veteran second baseman continues to be one of the more productive players in baseball. Cano could continue his impressive season when he brings his impressive lifetime .378 wOBA against right-handers (.338 vs. lefties) into a matchup with A's rookie righty Raul Alcantara (5.75 ERA, 1.33 WHIP).
Kyle Seager: With 30 homers and 99 RBIs across 581 at-bats, the third baseman has been one of the most productive players in the American League this season. Seager could drive in multiple runs when he takes his lifetime 129 wRC+ against right-handers (99 vs. lefties) into a matchup with the inexperienced righty Alcantara (20 1/3 innings).
Nolan Arenado: The third baseman could produce a notable DraftKings total when he brings his lifetime .281/.355/.498 slash line against left-handers and his lifetime .308/.355/.581 slash line at hitter-friendly Coors Field into a home matchup against Brewers southpaw Brent Suter, who will be making his second career start.
DJ LeMahieu: Among the hottest hitters in baseball, the second baseman has posted an overall .406/.479/.561 slash line since Aug. 1. LeMahieu could continue to rake when he brings his lifetime .850 OPS at Coors Field into a home matchup against the inexperienced southpaw Suter (16 2/3 innings)
Scooter Gennett: The second baseman owns lopsided lifetime splits, with a .779 OPS against right-handers in comparison to a .490 mark vs. lefties. Gennett could have a great game when he bats at hitter-friendly Coors Field against righty Chad Bettis (career 5.07 ERA, 1.49 WHIP) and a Rockies relief corps that ranks last in baseball with a 5.08 ERA.
Matt Carpenter: Carpenter could reach base often or score multiple runs out of the leadoff spot when he brings his lifetime 140 wRC+ against right-handers (114 vs. lefties) into a matchup with Pirates rookie righty Tyler Glasnow (4.91 ERA, 1.64 WHIP). Eligible at second base and third base, Carpenter presents DraftKings participants with multiple ways to fit him into a lineup.
Miguel Cabrera: With a lifetime .322/.389/.563 slash line against right-handers, the first baseman has proven to wield a potent bat during those matchups. Cabrera could post a substantial DraftKings total when he faces Braves righty Matt Wisler (career 4.79 ERA, 1.36 WHIP).
Cameron Maybin: With a lifetime .708 OPS against right-handers that exceeds his .666 mark vs. lefties, the outfielder could reach base often against the right-handed Wisler (4.86 ERA, 1.30 WHIP in 2016). Maybin could also swipe his 16th base of the season against catcher Tyler Flowers, who has thwarted three of 63 would-be basestealers in 2016.
Adam Eaton: From a premium lineup spot, the outfielder could reach base often or score multiple runs when he brings his lifetime .792 OPS against right-handers (.713 vs. lefties) into a matchup against righty Tyler Duffey (career 5.24 ERA, 1.42 WHIP) and a Twins bullpen that ranks 26th in the Majors with a 4.63 ERA.
Jean Segura: With an .899 OPS against right-handers this season that exceeds his .754 mark vs. lefties, the speedy second baseman could reach base often at the expense of righty Edwin Jackson (5.77 ERA, 1.60 WHIP in 2016) and a Padres bullpen that ranks 22nd in the Majors with a 4.08 ERA. Segura could also swipe his 32nd base of the season against Derek Norris, who has allowed more steals than any other catcher in 2016.
Curtis Granderson: The outfielder has long fared best vs. right-handers, against whom he has logged a lifetime .368 wOBA (.307 vs. lefties). Granderson could hit his 31st homer of the season or reach base often when he faces righty Alec Asher (career 6.04 ERA, 1.44 WHIP) and a Phillies bullpen that ranks 27th in baseball with a 4.95 ERA.
Jay Bruce: Hitting .200 as a member of the Mets, Bruce could have a reduced price tag in DraftKings contests when he brings his impressive 2016 totals of 32 homers and 96 RBIs across 530 at-bats into a matchup with Asher and an unreliable Phillies bullpen.
Ryan Schimpf: With 19 homers across 269 at-bats, the second baseman is quickly becoming one of the most powerful players at his premium position. Schimpf could put another ball into the outfield seats when he takes his lifetime .900 OPS against right-handers (.725 vs. lefties) into a matchup at homer-happy Chase Field against rookie righty Braden Shipley (5.26 ERA, 1.52 WHIP).
Robert Gsellman: With a 2.17 ERA across five September starts, the right-hander has been a major part of the Mets' postseason push. Gsellman could continue to limit the opposition when he faces a Phillies lineup that ranks 29th in baseball with a .693 OPS against righties.
Rich Hill: Having posted a 2.05 ERA and a 0.98 WHIP this season, the left-hander has the skills to spin a gem when he works at pitcher-friendly AT&T Park against a Giants lineup that ranks 23rd in baseball with a .710 OPS against southpaws. Hill's chances of earning a win could be enhanced by a Dodgers bullpen that leads the Majors with a 3.24 ERA.
Madison Bumgarner: DraftKings participants who do not select Hill may instead opt for his mound opponent. Bumgarner will be in great position to deliver a stellar start when he works at his pitcher-friendly home park against a Dodgers lineup that ranks last in the Majors with a .629 OPS against southpaws.
All statistics are accurate through the completion of Wednesday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.