The Comedy Central host and Major League Baseball's official Twitter entered Day 2 of their three-day pick-off tied at one game apiece after converting with Ethier and Ichiro Suzuki, respectively, on Monday night.
Colbert selected Pujols on Tuesday afternoon, Tweeting:
"Beat The Streak pick 6/14: Albert Pujols (StL) When I take over @MLB, I'll give fans what they want: lots of concession stand sales figures."
The Cardinals first baseman wasted little time making good for the "Colbert Report" host, launching a first-inning long ball off of Nationals starter Yunesky Maya.
Youkilis nearly extended the challenge to Day 3 with a shot down the third base line in his final at-bat, but a brilliant defensive play by Evan Longoria and Casey Kotchman sealed his hitless evening.
With a high streak of two, Colbert wins the challenge and will take control of @MLB at a future date. The 1.2 million baseball fans who follow MLB's official Twitter account can likely expect plenty of witty political banter, anti-bear propaganda and -- apparently -- concession stand financial statements.
Now in its 11th season, Beat the Streak takes just 15 seconds per day to play. Just pick one player who you think will get a hit during today's games. If you pick correctly, your streak continues. If you pick correctly 57 games in a row -- surpassing Joe DiMaggio's record 56-game hitting streak -- you could win $5.6 million.