BALTIMORE -- Red Sox second baseman Dustin Pedroia was out of the lineup for Tuesday night's 5-2 win against the Orioles so he could get treatment on his left knee, which has been nagging him for about 10 days.
"In the series in Toronto [from Sept. 9-11], he made that play up the middle and kind of twisted the knee a little bit on the throw," said Red Sox manager John Farrell. "It's a situation he's been managing since that series. After last night, though, there seemed there was a little more swelling in the knee and needed a day to recover and get some additional treatment."
It marked the first game off for Pedroia since Aug. 29, when he left the Red Sox for two games to attend a funeral for a family member. Farrell expects Pedroia back in the lineup on Wednesday, when Boston continues this four-game series.
Pedroia is having perhaps his best season in five years, slashing .325/.384/.452 with 13 homers and 67 RBIs.
Brock Holt left the Red Sox for two days due to a death in the family, and Farrell started Marco Hernandez at second base.
Due to the absence of Pedroia, Mookie Betts returned to leadoff for the first time since Aug. 9.
Ian Browne has covered the Red Sox for MLB.com since 2002. Follow him on Twitter @IanMBrowne and Facebook. This story was not subject to the approval of Major League Baseball or its clubs.