Despaigne did not make a start for the Orioles this season, but he started 34 games for the San Diego Padres over the previous two campaigns. He has the versatility to pitch in long relief or make spot starts for Miami, if necessary, as the club makes a late attempt for a National League Wild Card spot.
Andino, 32, played 13 games for the Marlins in 2016 and hit .292 with one RBI and two runs scored.
Oliver Macklin is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.