Crisp, who was in the starting lineup, left with an upset stomach.
He was originally slated to bat seventh, but when the Red Sox took the field in the bottom of the first, he was replaced by Wily Mo Pena.
Crisp is hitting .238 with a homer this season and Pena was hitting .229 with three homers entering Monday.
On the mend: Left-hander Jon Lester didn't let a little rain delay get in the way of a good rehab outing. Lester allowed one run on four hits in an 87-pitch outing on Monday, helping Triple-A Pawtucket to a 4-1 win over the Norfolk Tides.Lester has a 1.26 ERA over six starts spanning 28 2/3 innings with Pawtucket and is 1-1 with a 1.51 ERA overall, including three starts for Class A Greenville. "I got a text message back from him and he said he felt real good," Red Sox manager Terry Francona said. The former second-round draft pick faced four batters over the minimum, striking out one and issuing just one walk. Luis Montanez's leadoff homer in the sixth inning accounted for the Tides' only run. Lester is trying to revive his Major League career after being diagnosed with anaplastic large cell lymphoma last August. Mike Timlin also got into the act, allowing one hit in two scoreless innings in Pawtucket's second game against the Tides. He threw 21 pitches. "We'd like to get him one more inning in a couple of days and then activate him," Francona said. That would put Timlin on pace to rejoin the Red Sox for their weekend series in Arizona. Where's Drew? J.D. Drew returned to the lineup after missing two days with tendinitis. "I'll feel better when I see him out in right field," Francona said. "He's been running fine but I like to see him making breaks, things like that." Francona inserted Drew in the sixth spot to try to combat the plethora of left-handed relievers in the A's bullpen. "We try to construct the best lineup we can," Francona said. "We wanted to space it out and get some balance because of the schedule." Friendly fans: The Red Sox have always had a good following wherever they played, and Oakland is no exception. "We get a boost everywhere we go," Doug Mirabelli said. "It seems like we have as many fans as the home team. The Red Sox nation picks us up." The Red Sox needed a boost after traveling all night from Boston to Oakland, arriving in the Bay Area about 4:30 a.m. PT on Monday and getting into their rooms by 5:30 p.m. "I might have napped," Francona said. Up next: Dice-K mania hits the West Coast as right-hander Daisuke Matsuzaka (7-3, 4.83) starts Tuesday in a 10:05 p.m. ET contest against former Red Sox Lenny DiNardo (1-2, 2.80).
Rick Eymer is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.