Josh Donaldson: Since joining the Blue Jays at the outset of 2015, the third baseman has posted a 1.020 OPS against left-handers (.935 vs. righties) and a 1.035 OPS at his hitter-friendly home park (.869 on the road). Donaldson could post a game-changing DraftKings total when he hits at home against Red Sox southpaw Eduardo Rodriguez (4.83 ERA, 1.30 WHIP in 2016).
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Troy Tulowitzki: The shortstop will be in great position to hit his 23rd homer of the season or drive in multiple runs when he brings his lifetime .403 wOBA against left-handers (.363 vs. righties) into a matchup with the left-handed Rodriguez (career 4.24 ERA, 1.30 WHIP).
Eric Hosmer: From the heart of the lineup, the first baseman could hit a homer or drive in multiple runs when he brings his lifetime .806 OPS against right-handers (.687 vs. lefties) into a matchup at homer-happy U.S. Cellular Field against fly-ball-prone righty James Shields (6.07 ERA, 2.1 HR/9 rate in 2016).
Mike Napoli: With 31 homers and 92 RBIs across 486 at-bats, the first baseman has been one of the most powerful players in the American League this season. Napoli could have a great game when he takes his lifetime 144 wRC+ against left-handers (115 vs. righties) into a matchup southpaw Hector Santiago (4.91 ERA, 1.38 WHIP in 2016) and a Twins bullpen that ranks 26th in baseball with a 4.72 ERA.
Brandon Guyer: The outfielder has produced substantial splits this season, with a 1.014 OPS against left-handers in comparison to a .619 mark vs. righties. Guyer could excel against the left-handed Santiago (career 4.71 FIP, 1.34 WHIP) and a Twins squad that ranks last in the Majors with a .661 defensive efficiency ratio.
Gregory Polanco: The outfielder could reach base often or display his power when he brings his lifetime .330 wOBA against right-handers (.262 vs. lefties) into a matchup with rookie righty Robert Stephenson (5.71 FIP) and a Reds bullpen that ranks 28th in baseball with a 5.00 ERA. Polanco could also swipe a base against Tucker Barnhart, who has allowed more steals than all but one catcher in 2016.
Miguel Cabrera: With a lifetime .322/.389/.562 slash line against right-handers, the first baseman has proven to be one of the best in baseball during those matchups. Cabrera could have an excellent game when he faces Orioles righty Ubaldo Jimenez (6.19 ERA, 1.68 WHIP in 2016).
Matt Carpenter: With 18 homers and a .389 on-base percentage across 479 plate appearances this season, the second baseman has the skills to maximize his opportunities from the leadoff spot when he brings his lifetime .868 OPS against right-handers (.780 vs. lefties) into a matchup with Brewers righty Chase Anderson (4.73 ERA, 1.39 WHIP in 2016).
Brandon Moss: With a lifetime .232 ISO against right-handers (.156 vs. lefties), the left-handed-hitting first baseman will be in prime position to rip his 26th round-tripper of the season or drive in multiple runs when he tangles with the right-handed Anderson (career 4.36 ERA, 1.35 WHIP).
Brandon Belt: Having hit 56 of his lifetime 78 homers on the road, the first baseman could put a ball into the outfield seats when he vacates his pitcher-friendly home park and bats at homer-happy Chase Field against righty Archie Bradley (career 5.07 ERA, 1.55 WHIP). Belt could also thrive late in the game against a D-backs bullpen that ranks last in the Majors with a 5.13 ERA.
Ryan Schimpf: With 18 homers across 215 at-bats, the second baseman is quickly emerging as one of the most powerful players at his premium position. Schimpf could put a ball into the outfield seats when he brings his .976 OPS against right-handers (.824 vs. lefties) into a matchup with righty Jon Gray (career 4.73 ERA, 1.32 WHIP) and a Rockies relief corps that ranks 29th in baseball with a 5.07 ERA.
Curtis Granderson: Hitting leadoff, the outfielder may maximize his opportunities to reach base and score runs when he brings his lifetime 128 wRC+ against right-handers (87 vs. lefties) into a matchup with rookie righty John Gant (4.70 ERA, 1.38 WHIP) and a Braves bullpen that ranks 21st in baseball with a 4.14 ERA.
Jay Bruce: The outfielder could display his power when he brings his lifetime .815 OPS against right-handers (.713 vs. lefties) into a matchup with the inexperienced righty Gant (38 1/3 innings) and an unreliable Braves bullpen.
Seth Lugo: Since joining the Mets rotation on Aug. 19, the right-hander has gone 3-1 with a 2.19 ERA and a 1.01 WHIP. Lugo could continue to limit the opposition when he works at pitcher-friendly Turner Field against a Braves lineup that ranks 26th in baseball in OPS vs. righties (.703) and last in total home runs (100).
Adam Wainwright: With a 4.61 ERA this season, the right-hander could have a reasonable DraftKings price tag when he works at his pitcher-friendly home park against a Brewers lineup that ranks 21st in the Majors in OPS vs. righties (.724) and first in total strikeouts (1,328).
Rich Hill: Although he has battled injuries, the left-hander has produced an impressive 1.94 ERA ERA and a 1.03 WHIP this season. Hill could continue his stellar campaign when he faces a Marlins lineup that ranks 22nd in the Majors with a .729 OPS against southpaws.
Max Scherzer: Having posted a 2.93 ERA, a 1.00 WHIP and a 10.6 K/9 rate since the outset of 2013, the right-hander ranks among the most dominant pitchers in baseball. Scherzer could post a game-changing DraftKings total when he works at home against a Phillies lineup that ranks 29th in baseball in OPS vs. righties (.687) and 21st in OPS on the road (.707).