The players listed below are in position to provide difference-making stats for DraftKings participants on Saturday.
Carlos Gonzalez: In his career, the outfielder has fared best when facing right-handers (.929 OPS) and when batting at his hitter-friendly home park (1.020 OPS). CarGo could have a memorable game when he hits at home against rookie righty Braden Shipley (4.75 ERA, 1.42 WHIP) and a D-backs bullpen that ranks last in baseball with a 5.08 ERA.
Charlie Blackmon: Like his teammate Gonzalez, Blackmon has excelled against right-handers (lifetime .817 OPS) and at his offense-inducing home park (lifetime .886 OPS). The outfielder may maximize the benefits of his leadoff spot to collect multiple hits and runs against Shipley (5.87 FIP) and a D-backs squad that ranks 29th in baseball with a .665 defensive efficiency ratio.
DJ LeMahieu: With an overall .439/.534/.643 slash line since Aug. 1, the second baseman will bring a red-hot bat and a lifetime .848 OPS at his hitter-friendly home park into a favorable matchup against Shipley and an unreliable D-backs relief corps.
Corey Seager: Hitting .315 with 23 homers and 88 runs across 568 plate appearances, the shortstop is coming down the stretch of a memorable rookie season. Seager could continue to excel when he brings his impressive lifetime .335/.398/.566 slash line against right-handers into a matchup with Padres rookie righty Luis Perdomo (5.84 ERA, 1.70 WHIP).
Adrian Gonzalez: Hitting .294 with 75 RBIs across 476 at-bats, the first baseman continues to be one of the most dependable hitters in baseball. Gonzalez could thrive when he brings his lifetime 140 wRC+ against right-handers (109 vs. lefties) into a matchup with Perdomo and a Padres bullpen that ranks 26th in baseball with a 4.45 ERA.
Justin Turner: From the heart of the lineup, the third baseman could go deep or drive in multiple runs when he brings his lifetime .825 OPS against right-handers (.701 vs. lefties) into a matchup with the inexperienced Perdomo (4.66 FIP) and an unreliable Padres bullpen.
Jake Lamb: In his breakout 2016 season, the third baseman has produced a .932 OPS against right-handers that exceeds his .614 mark vs. lefties. Lamb will be in prime position to display his power when he bats at homer-happy Coors Field against righty Chad Bettis (career 5.20 ERA, 1.53 WHIP) and a Rockies relief corps that ranks 28th in the Majors with a 5.02 ERA.
Todd Frazier: The third baseman will be in excellent position to hit his 35th homer of the season or drive in multiple runs when he brings his lifetime .828 OPS against left-handers (.762 vs. righties) into a matchup with southpaw Hector Santiago (4.93 ERA, 1.39 WHIP in 2016) and a Twins bullpen that ranks 25th in the Majors with a 4.41 ERA.
Mark Trumbo: With a 40 homers and 96 RBIs across 510 at-bats, the outfielder has been arguably the most powerful player in baseball this season. Trumbo could put a ball into the outfield seats when he brings his lifetime .244 ISO against left-handers (.210 vs. righties) into a matchup at his hitter-friendly home park against Yankees southpaw CC Sabathia (4.31 ERA, 1.35 WHIP in 2016).
Odubel Herrera: The second-year outfielder will be in great position to improve on his lifetime 118 wRC+ against right-handers (82 vs. lefties) when he faces Braves rookie righty John Gant (4.59 ERA, 1.41 WHIP).
Gregory Polanco: > With 21 homers, 79 RBIs and 12 steals across 485 plate appearances, Polanco has the diverse skill set that DraftKings participants covet. The outfielder could contribute in multiple ways when he brings his lifetime 113 wRC+ against right-handers (65 vs. lefties) into a matchup with Brewers righty Jimmy Nelson, who in his career has allowed left-handed hitters such as Polanco to post an .817 OPS (.681 OPS allowed to righty batters).
Max Kepler: The outfielder owns notable lifetime splits, with a .352 wOBA against right-handers in comparison to a .274 mark vs. lefties. Kepler could hit his 17th homer of the season or drive in multiple runs when he faces the fly-ball-prone White Sox righty James Shields (5.86 ERA, 1.9 HR/9 rate in 2016).
Bryce Harper: The reigning National League MVP could be one of the most productive outfielders in baseball on Saturday when he brings his impressive lifetime .294/.400/.539 slash line against right-handers into a matchup with righty Robert Gsellman, who will be making his second career start.
Daniel Murphy: With 25 homers and 98 RBIs across 475 at-bats, the second baseman has been one of the most productive players in the National League this season. Hitting behind Harper, Murphy could drive in multiple runs when he brings his lifetime .810 wRC+ against right-handers (.707 vs. lefties) into a matchup with Gsellman (1.34 WHIP).
Rick Porcello: With an 18-3 record, a 3.26 ERA and a 1.04 WHIP, the right-hander is putting the finishing touches on an outstanding bounce-back season. Porcello could continue to limit the opposition when he works at pitcher-friendly Oakland Coliseum against an A's lineup that ranks 27th in baseball with a .697 OPS against righties.
Ivan Nova: Having posted a 22-to-1 strikeout-to-walk ratio across five starts since joining the Pirates, Nova will be in fine form heading into an outing at his pitcher-friendly home park against a Brewers lineup that ranks 24th in baseball in OPS vs. righties (.714) and first in total strikeouts (1,277).
Michael Fulmer: With a 2.69 ERA and a 1.06 WHIP, the right-hander has been arguably the most effective rookie starter in baseball this season. Fulmer could continue his stellar debut when he works at offense-suppressing Kauffman Stadium against a Royals lineup that ranks last in baseball with a .129 ISO against righties.
All statistics are accurate through the completion of Thursday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB. This story was not subject to the approval of Major League Baseball or its clubs.