The players listed below are in position to provide difference-making stats for DraftKings participants on Friday.
Nolan Arenado: In his career, the third baseman has fared best when facing left-handers (.870 OPS) and batting at his hitter-friendly home park (.940 OPS). Arenado could have a memorable game when he hits at home against southpaw Robbie Ray (career 4.33 ERA, 1.43 WHIP) and a D-backs bullpen that ranks last in baseball with a 5.08 ERA.
DJ LeMahieu: With an overall .439/.534/.643 slash line since Aug. 1, the second baseman will bring a red-hot bat and lifetime .848 OPS at his hitter-friendly home park into a favorable matchup against the left-handed Ray (4.28 ERA, 1.43 WHIP in 2016) and a D-backs squad that ranks 29th in baseball with a .665 defensive efficiency ratio.
Paul Goldschmidt: With a lifetime .332/.436/.600 slash line against left-handers, the first baseman has proved to wield a potent bat during those matchups. Goldschmidt could put a ball into the outfield seats when he faces southpaw Jorge De La Rosa (career 4.60 ERA, 1.44 WHIP) at homer-happy Coors Field.
Welington Castillo: As a big leaguer, the catcher has registered an .861 OPS against left-handers in comparison to a .698 mark vs. righties. Castillo could rip a round-tripper or drive in multiple runs when he bats at Colorado's hitter-friendly venue against the left-handed De La Rosa (5.09 ERA, 1.54 WHIP in 2016) and a Rockies relief corps that ranks 28th in the Majors with a 5.02 ERA.
Yasmany Tomas: Since arriving to the Majors at the outset of 2015, the outfielder has posted a 133 wRC+ against left-handers that exceeds his 85 mark vs. righties. Tomas could hit his 28th homer of the season when he tangles with the left-handed De La Rosa and a Rockies squad that ranks 28th in baseball with a .674 defensive efficiency ratio.
Chris Davis: The left-handed-hitting first baseman will be in prime position to display his power when he brings his lifetime .870 OPS against right-handers (.740 vs. lefties) into a matchup at his hitter-friendly home park against Yankees rookie righty Chad Green (4.09 ERA, 1.30 WHIP). Also working in Davis' favor: Camden Yards has proved to be especially power-inducing for southpaw sluggers.
Jonathan Schoop: With 21 homers and 70 RBIs across 503 at-bats, the second baseman has been one of the most powerful players at his premium position this season. Schoop could excel when he brings his lifetime .764 OPS against right-handers (.612 vs. lefties) into a matchup with the rookie righty Green (5.09 FIP).
Jay Bruce: With 27 homers and 86 RBIs across 463 at-bats, the outfielder has been one of the most powerful players in the National League this season. Bruce could have a great game when he brings his lifetime 114 wRC+ against right-handers (91 vs. lefties) into a matchup with Nationals righty A.J. Cole (career 5.32 ERA, 1.32 WHIP).
David Ortiz: Much of the slugger's legendary lifetime success has been fueled by an impressive .294/.397/.584 slash line against right-handers. Ortiz could go deep or drive in multiple runs when he faces A's rookie righty Andrew Triggs (4.39 ERA).
Mike Trout: With a lifetime .287/.399/.515 slash line against left-handers, the outfielder has proven to be one of the best in baseball during those matchups. Trout could post a game-changing DraftKings total when he faces Mariners rookie lefty Ariel Miranda (5.70 ERA, 1.48 WHIP).
Odubel Herrera: The second-year outfielder will be in great position to improve on his lifetime 118 wRC+ against right-handers (82 vs. lefties) when he faces rookie righty Joel De La Cruz (4.66 ERA, 1.41 WHIP) and a Braves bullpen that ranks 23rd in baseball with a 4.23 ERA.
Freddy Galvis: With a lifetime .658 OPS against right-handers (.601 vs. lefties), the shortstop could be in prime position to deliver when he faces the rookie righty De La Cruz (5.37 FIP). Galvis could also swipe his 13th base of the season against catcher Tyler Flowers, who has thwarted just two of 44 would-be base stealers in 2016.
Eric Hosmer: At the heart of a surging Royals lineup, Hosmer could reach base often or drive in multiple runs when he brings his lifetime .346 wOBA against right-handers (.300 vs. lefties) into a matchup with righty Anibal Sanchez (5.92 ERA, 1.47 WHIP in 2016) and a Tigers bullpen that ranks 21st in baseball with a 4.13 ERA.
Joey Votto: With an overall .423/.516/.678 slash line since the All-Star break, the first baseman will be in fine form when he brings his lifetime .317/.436/.549 slash line against right-handers into a matchup with Cardinals rookie righty Alex Reyes, who has thrown just 14 big league innings.
Carlos Correa: This season, the second-year shortstop has produced an .863 OPS against right-handers that exceeds his .752 mark vs. lefties. From the heart of the lineup, Correa could hit a homer or drive in multiple runs when he bats at homer-happy Globe Life Park in Arlington against fly-ball-prone righty A.J. Griffin (4.39 ERA, 1.8 HR/9 rate in 2016).
David Price: With a 2.44 ERA and a 1.08 WHIP across his past seven starts, the left-hander is back in ace form after a slow start to the season. Price could spin a gem when he works at pitcher-friendly Oakland Coliseum against an A's lineup that ranks 24th in the Majors with a .702 OPS against southpaws.
Jeremy Hellickson: With a 3.07 ERA and a 1.06 WHIP across his past 12 starts, the right-hander is in fine form heading into a favorable matchup against a Braves lineup that ranks 29th in baseball in ISO vs. righties (.132) and last in total home runs (92).
All statistics are accurate through the completion of Wednesday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.