The players listed below are in position to provide difference-making stats for DraftKings participants on Thursday.
Anthony Rizzo: The first baseman could add to his impressive 2016 totals of 26 homers and 93 RBIs across 479 at-bats when he brings his lifetime .227 ISO against right-handers (.183 vs. lefties) into a matchup with Giants righty Jeff Samardzija (4.00 ERA in 2016).
Kris Bryant: Hitting .305 with 35 homers, 89 RBIs and 109 runs across 579 plate appearances, the third baseman has been one of the most productive players in the Majors this season. From the heart of a Cubs lineup that ranks third with 666 runs scored, Bryant could post a substantial DraftKings total when he brings his balanced career splits into a matchup with Samardzija.
Addison Russell: The second-year shortstop will be poised to improve on his lifetime 100 wRC+ against right-handers (78 vs. lefties) when he tangles with Samardzija, who has posted a 5.13 ERA and a 1.33 WHIP across his past 12 starts.
Jason Heyward: Hitting .231 with six homers across 442 at-bats this season, the outfielder could have a reduced price tag in DraftKings contests when he brings his solid lifetime .812 OPS against right-handers (.654 vs. lefties) into a matchup with Samardzija (4.54 ERA since the outset of 2015). In his career, Samardzija has allowed left-handed hitters such as Heyward to post a .764 OPS (.676 OPS allowed to righty batters).
Alex Dickerson: The outfielder will be in great position to improve on his lifetime .783 OPS against right-handers (.635 vs. lefties) when he faces righty Mike Foltynewicz (career 4.98 ERA, 1.46 WHIP). Dickerson could also excel late in the game against a Braves bullpen that ranks 23rd in the Majors with a 4.26 ERA.
Travis Jankowski: With a lifetime .731 OPS against right-handers that exceeds his .477 mark vs. lefties, the outfielder has the skills to reach base often and score multiple runs when he faces Foltynewicz (4.30 ERA, 1.29 WHIP in 2016). Jankowski could also swipe his 30th base of the season at the expense of catcher Tyler Flowers, who has thwarted two of 43 would-be basestealers in 2016.
Ryan Schimpf: With 16 homers across 190 at-bats, the rookie second baseman is quickly becoming one of the most powerful players at his premium position. Schimpf could go deep or drive in multiple runs when he brings his .384 ISO against right-handers (.296 vs. lefties) into a matchup with Foltynewicz, who in his career has allowed left-handed hitters such as Schimpf to post a .911 OPS (.766 OPS allowed to righty batters).
Freddie Freeman: Hitting .290 with 27 homers across 487 at-bats, the first baseman has quietly been one of the most effective hitters in the National League this season. Freeman could have a great game when he brings his lifetime .895 OPS against right-handers (.753 vs. lefties) into a matchup with Padres righty Jarred Cosart (career 4.18 FIP, 1.40 WHIP).
Nick Markakis: As a big leaguer, the outfielder has registered a .809 OPS against right-handers in comparison to a .728 mark vs. lefties. Markakis could reach base often or drive in multiple runs when he faces Cosart (4.23 ERA, 1.66 WHIP in 2016) and a Padres bullpen that ranks 24th in the Majors with a 4.38 ERA.
Ender Inciarte: The outfielder could reach base often or score multiple runs when he brings his lifetime 104 wRC+ against right-handers (67 vs. lefties) into a matchup with Cosart and an unreliable Padres bullpen. Inciarte could also swipe a base against Derek Norris, who has allowed more steals than any other catcher in 2016.
Jace Peterson: The second baseman could provide cost-effective production at a premium position when he brings his lifetime .688 OPS against right-handers (.528 vs. lefties) into a matchup with Cosart and a Padres squad that ranks 22nd in the Majors with a .683 defensive efficiency ratio.
Curtis Granderson: Hitting leadoff, the outfielder may maximize his opportunities to reach base and score runs when he takes his lifetime .854 OPS against right-handers (.694 vs. lefties) into a matchup with Marlins righty Jose Urena (5.83 ERA, 1.44 WHIP in 2016).
James Loney: With a lifetime .337 wOBA against right-handers in comparison to a .285 mark vs. lefties, the first baseman will be in prime position to thrive against Urena (career 5.52 ERA, 1.52 WHIP). In his career, Urena has allowed left-handed hitters such as Loney to post an .874 OPS (.733 OPS allowed to righty batters).
Jay Bruce: With 27 homers and 86 RBIs across 459 at-bats, the outfielder has been one of the most powerful players in the National League this season. Bruce could put a ball into the outfield seats when he brings his lifetime .813 OPS against right-handers (.716 vs. lefties) into a matchup against Urena.
Yoenis Cespedes: With balanced career splits, the outfielder could add to his impressive 2016 statistics (27 homers, 68 RBIs across 373 at-bats) when he faces Urena (career 4.62 FIP).
Jacob deGrom: The right-hander has the skills to deliver a stellar start when he brings his impressive lifetime 2.71 ERA and 1.09 WHIP into a matchup against a Marlins lineup that ranks 20th in the Majors with a .729 OPS against righties and will work without injured slugger Giancarlo Stanton.
Ervin Santana: With a 2.30 ERA and a 0.96 WHIP across his past 12 starts, the right-hander is in fine form heading into a favorable home matchup against a White Sox lineup that ranks 25th in the Majors with a .705 OPS against righties.
All statistics are accurate through the completion of Tuesday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB. This story was not subject to the approval of Major League Baseball or its clubs.