Ian Kinsler: The second baseman has long fared best vs. left-handers, against whom he has produced a lifetime .878 OPS (.761 vs. righties). Hitting leadoff, Kinsler may maximize his opportunities to excel against Angels southpaw Tyler Skaggs (career 4.86 ERA, 1.34 WHIP).
J.D. Martinez: Hitting .414 with six homers across 93 plate appearances since coming off the disabled list on Aug. 3, the outfielder will bring a hot bat and a lifetime .236 ISO against left-handers (.192 vs. righties) into a matchup with the left-handed Skaggs. Martinez could also excel late in the game against an Angels bullpen that will work without injured anchors Huston Street and Cam Bedrosian.
James McCann: The catcher owns lopsided lifetime splits, with an .880 OPS against left-handers in comparison to a .587 mark vs. righties. McCann could provide cost-effective production at a premium position when he faces the left-handed Skaggs, who has logged a 5.70 ERA and a 1.67 WHIP across six starts since returning from Tommy John surgery.
Bryce Harper: Hitting .400 with a 1.152 OPS across 59 plate appearances since Aug. 15, the superstar outfielder has rebounded from a midseason slump. Harper could post a substantial DraftKings total when he takes his lifetime .295/.402/.542 slash line against right-handers into a matchup with righty Chad Bettis (career 5.25 ERA, 1.54 WHIP) and a Rockies relief corps that ranks 28th in baseball with a 4.94 ERA.
Daniel Murphy: Hitting .346 with 25 homers and 98 RBIs across 502 plate appearances, the second baseman has been one of the most productive players in baseball this season. Batting behind Harper, Murphy could drive in multiple runs when he brings his lifetime .812 OPS against right-handers (.709 vs. lefties) into a matchup with the right-handed Bettis (5.29 ERA, 1.51 WHIP in 2016) and a Rockies squad that ranks 28th in baseball with a .686 defensive efficiency ratio.
Christian Yelich: Hitting .309 with a .383 on-base percentage this season, the outfielder has the skills to reach base often and score multiple runs when he brings his lifetime 133 wRC+ against right-handers (95 vs. lefties) into a matchup with rookie righty Luis Perdomo (6.24 ERA, 1.76 WHIP) and a Padres bullpen that ranks 25th in baseball with a 4.41 ERA.
Odubel Herrera: The second-year outfielder will be in great position to improve on his lifetime 119 wRC+ against right-handers (82 vs. lefties) when he faces Mets righty Robert Gsellman, who will be making his first career start.
Joey Votto: The first baseman has used a patient, powerful approach to build an impressive lifetime .317/.436/.548 slash line against right-handers. Votto could reach base often or score multiple runs when he bats at hitter-friendly Chase Field against righty Archie Bradley (career 5.25 ERA, 1.59 WHIP) and a D-backs bullpen that ranks last in the Majors with a 5.11 ERA.
Matt Carpenter: Eligible at second base and third base in DraftKings contests, Carpenter could enter DraftKings lineups in multiple ways when he brings his lifetime .870 OPS against right-handers (.778 vs. lefties) into a matchup with A's rookie righty Andrew Triggs (4.38 ERA, 1.30 WHIP).
Brandon Moss: With a lifetime .236 ISO against right-handers in comparison to a .156 mark vs. lefties, the first baseman will be in prime position to hit his 26th homer of the season or drive in multiple runs when he faces the inexperienced righty Triggs (49 1/3 innings in his Major League career).
Mike Napoli: With 29 homers and 88 RBIs across 515 plate appearances, the first baseman has been one of the most powerful players in baseball this season. Napoli could put a ball into the outfield seats when he brings his lifetime 145 wRC+ against left-handers (116 vs. righties) into a matchup against southpaw Derek Holland (career 4.33 ERA, 1.32 WHIP) at hitter-friendly Globe Life Park in Arlington.
Brandon Guyer: The outfielder could reach base often or score multiple runs when he brings his lifetime .858 OPS against left-handers (.642 vs. righties) into a matchup with the left-handed Holland (4.92 ERA, 1.37 WHIP in 2016) and a Rangers relief corps that ranks 27th in baseball with a 4.85 ERA.
Denard Span: The outfielder will be in prime position to collect multiple hits and runs when he takes his lifetime .761 OPS against right-handers (.703 vs. lefties) into a matchup with Braves rookie righty Aaron Blair (7.99 ERA, 1.76 WHIP). Span could also swipe a base against catcher Tyler Flowers, who has thrown out two of 42 would-be basestealers in 2016.
Gregory Polanco: With 19 homers, 75 RBIs and 11 steals across 467 plate appearances, the outfielder has the skills to contribute to DraftKings squads in multiple ways when he brings his lifetime .770 OPS against right-handers (.605 vs. lefties) into a matchup with Brewers righty Chase Anderson (4.99 ERA, 1.42 WHIP in 2016).
Jon Lester: Having posted a 3.11 ERA and a 1.10 WHIP since joining the Cubs at the outset of 2015, the left-hander already ranks among the most effective starters in the National League. Lester could spin a gem when he works at pitcher-friendly Dodger Stadium against a Los Angeles lineup that ranks last in the Majors with a .653 OPS against southpaws.
Madison Bumgarner: With a 2.44 ERA and a 1.05 WHIP, the left-hander continues to rank among the most reliable aces in baseball. Bumgarner could post a substantial DraftKings total when he works at his pitcher-friendly home park against a Braves lineup that ranks last in baseball in ISO vs. lefties (.101) and total home runs (90).
All statistics are accurate through the completion of Friday's games.