Danny Espinosa: With a lifetime 114 wRC+ against left-handers (79 vs. righties), the shortstop could thrive against southpaw Jorge De La Rosa (5.07 ERA, 1.53 WHIP in 2016) and a Rockies relief corps that ranks 28th in baseball with a 4.93 ERA. Also of note: Espinosa will attempt to put balls into play against a Colorado squad that ranks 28th in the Majors with a .672 defensive efficiency ratio.
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Jayson Werth: As a big leaguer, Werth has produced a .938 OPS against left-handers that exceeds his .783 mark vs. righties. The outfielder could reach base often against the left-handed De La Rosa, who in his career has allowed right-handed hitters such as Werth to post a .795 OPS (.647 OPS allowed to lefty batters).
Joey Votto: The first baseman has used a patient, powerful approach to build an impressive lifetime .317/.436/.548 slash line against right-handers. Votto could reach base often or score multiple runs when he bats at hitter-friendly Chase Field against righty Zack Godley (career 4.61 ERA, 1.35 WHIP) and a D-backs bullpen that ranks last in the Majors with a 5.14 ERA.
Miguel Cabrera: With a lifetime .322/.389/.563 slash line against right-handers, the first baseman has proven to be one of the best in baseball during those matchups. Cabrera could hit his 29th homer of the season or drive in multiple runs when he tangles with Angels righty Jhoulys Chacin (5.61 ERA, 1.53 WHIP in 2016).
Matt Carpenter: Eligible at second base and third base in DraftKings contests, Carpenter could enter DraftKings lineups in multiple ways when he brings his lifetime .871 OPS against right-handers (.778 vs. lefties) into a matchup with A's rookie righty Zach Neal (5.49 ERA).
Brandon Moss: With a lifetime .236 ISO against right-handers in comparison to a .158 mark vs. lefties, the first baseman will be in prime position to hit his 26th homer or the season or drive in multiple runs when he faces the inexperienced righty Neal (39 1/3 innings).
Jason Kipnis: From a premium lineup spot, the second baseman could thrive in a matchup against fly-ball-prone righty A.J. Griffin (4.68 ERA, 1.9 HR/9 rate in 2016) at homer-happy Globe Life Park in Arlington. In his career, Kipnis has produced a .352 wOBA against right-handers that exceeds his .302 mark vs. lefties.
Tyler Naquin: The rookie outfielder will be in prime position to improve on his impressive .318/.371/.596 slash line against right-handers when he bats at Texas' hitter-friendly venue against the homer-prone Griffin and a Rangers relief corps that ranks 27th in the Majors with a 4.69 ERA.
Denard Span: The outfielder will be in prime position to collect multiple hits and runs when he takes his lifetime .761 OPS against right-handers (.703 vs. lefties) into a matchup with Braves righty Mike Foltynewicz (career 5.12 ERA, 1.48 WHIP). Span could also swipe a base against catcher Tyler Flowers, who has thrown out two of 42 would-be base stealers in 2016.
Brandon Crawford: With balanced career splits, the shortstop could provide production at a premium position when he faces Foltynewicz (4.55 ERA, 1.33 WHIP in 2016). In his career, Foltynewicz has allowed left-handed hitters such as Crawford to post a .918 OPS (.776 OPS allowed to righty batters).
Marcell Ozuna: Hitting .203 since the All-Star break, the outfielder could have a reduced price tag in DraftKings contests when he brings his lifetime 136 wRC+ against left-handers (96 vs. righties) into a matchup with southpaw Clayton Richard (career 4.31 ERA, 1.40 WHIP) and a Padres bullpen that ranks 25th in baseball with a 4.34 ERA.
Adeiny Hechavarria: Hitting .249 with three homers and one steal across 449 plate appearances this season, the shortstop could be a cost-effective option at a premium position in DraftKings contests when he takes his lifetime .681 OPS against left-handers (.621 vs. righties) into a matchup with the left-handed Richard. In his career, Richard has allowed right-handed hitters such as Hechavarria to post an .806 OPS (.612 OPS allowed to lefty batters).
Jameson Taillon: Having posted a 2.92 ERA and a 1.04 WHIP, the right-hander has been one of the most effective rookie starters in baseball this season. Taillon could compile six-plus effective innings and a handful of strikeouts when he faces a Brewers lineup that leads the Majors with 1,203 whiffs.
Michael Fulmer: With a 1.86 ERA and a 0.89 WHIP across his past 16 starts, the right-hander has been one of the best starters in the American League this summer. Fulmer could continue to excel when he works at home against an Angels lineup that ranks 19th in the Majors with a .724 OPS against righties.
Noah Syndergaard: The right-hander could spin a gem when he brings his lifetime 2.93 ERA and 10.4 K/9 rate into a home matchup against a Phillies lineup that ranks 27th in baseball in OPS vs. righties (.700) and 29th in total runs scored (479).
All statistics are accurate through the completion of Thursday's games.