MLB.com Columnist

Fred Zinkie

Rizzo, Miggy, Fernandez poised to excel

Rangers' Darvish, Nationals' Werth could join trio as top picks to click

Rizzo, Miggy, Fernandez poised to excel

Welcome to DraftKings fantasy baseball, the Official Daily Fantasy Game of Major League Baseball.

The players listed below are in position to provide difference-making stats for DraftKings participants on Wednesday.

Anthony Rizzo: With 25 homers, 87 RBIs and a .399 on-base percentage across 531 plate appearances, the first baseman has been one of the most productive players in baseball this season. Rizzo could post a substantial DraftKings total when he brings his lifetime .229 ISO against right-handers (.186 vs. lefties) into a matchup with Padres righty Paul Clemens (career 5.32 ERA, 1.54 WHIP).

Addison Russell: The second-year shortstop will be in great position to improve on his lifetime 104 wRC+ against right-handers (77 vs. lefties) when he faces the right-handed Clemens (4.82 ERA, 1.58 WHIP in 2016) and a Padres bullpen that ranks 25th in baseball with a 4.40 ERA.

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Jason Heyward: Hitting .225 with six homers across 413 at-bats this season, the outfielder could have a reduced price tag in DraftKings contests when he brings his solid lifetime .811 OPS against right-handers (.657 vs. lefties) into a matchup with the right-handed Clemens and an unreliable Padres bullpen. Heyward could be part of a productive lineup, as the Cubs rank third in baseball with 636 runs scored.

Miguel Cabrera: With a lifetime .322/.389/.562 slash line against right-handers, the first baseman has proven to be one of the best in baseball during those matchups. From the heart of a productive Tigers lineup, Cabrera could excel in a matchup against righty Tyler Duffey (career 4.97 ERA, 1.40 WHIP) and a Twins bullpen that ranks 22nd in baseball with a 4.25 ERA.

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Cameron Maybin: With balanced career splits, the speedy outfielder could thrive against Duffey (5.93 ERA, 1.45 WHIP in 2016) and an unreliable Twins bullpen. Maybin could also swipe a base against catcher Kurt Suzuki, who sometimes struggles to thwart would-be basestealers.

Danny Espinosa: As a big leaguer, the shortstop has produced a .783 OPS against left-handers in comparison to a .665 mark vs. righties. On Wednesday, Espinosa could provide production at a premium position when he tangles with Orioles southpaw Wade Miley (career 4.17 ERA, 1.35 WHIP).

Jayson Werth: The outfielder has long fared best vs. left-handers, against whom he has a lifetime 149 wRC+ (113 vs. righties). As part of a Nats lineup that ranks fourth in the Majors with a .790 OPS against southpaws, Werth could reach base often or score multiple runs at the expense of the left-handed Miley (5.58 ERA, 1.43 WHIP in 2016).

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Christian Yelich: Hitting .314 with 15 homers and 72 RBIs across 446 at-bats, the outfielder has been a major factor in many 2016 DraftKings contests. Yelich could reach base often or drive in multiple runs when he brings his lifetime .839 OPS against right-handers (.696 vs. lefties) into a matchup with Royals righty Dillon Gee (4.52 ERA, 1.52 WHIP in 2016).

Stephen Vogt: In his career, the catcher has logged a .768 OPS against right-handers in comparison to a .607 mark vs. lefties. Vogt could provide production at a premium position when he faces Indians righty Trevor Bauer (career 4.32 ERA, 1.36 WHIP).

Gregory Polanco: With a lifetime 112 wRC+ against right-handers (61 vs. lefties), the outfielder could collect multiple hits or RBIs when he faces Astros righty Collin McHugh (4.99 ERA, 1.52 WHIP in 2016). Polanco could also steal a base against catcher Jason Castro, who has thrown out seven of 37 would-be basestealers in 2016.

Nomar Mazara: The rookie outfielder will be in prime position to improve on his .297/.355/.473 slash line against right-handers when he faces rookie righty Tim Adleman (4.96 FIP, 1.40 WHIP) at offense-inducing Great American Ball Park. Mazara could also thrive late in the game against a Reds relief corps that ranks 29th in baseball with a 5.07 ERA.

Mitch Moreland: With a lifetime .206 ISO against right-handers (.140 vs. lefties), the first baseman could rip his 22nd round-tripper of the season or drive in multiple runs when he faces the inexperienced righty Adleman (24 1/3 innings) and an unreliable Reds bullpen at Cincy's homer-happy venue.

Zack Greinke: With a 4.21 ERA this season, the ace right-hander could have a reduced price tag in DraftKings contests when he faces a Braves lineup that ranks 29th in the Majors in ISO vs. righties (.132) and last in total home runs (88).

Greinke holds Padres to two runs

Kyle Hendricks: Having posted a 2.16 ERA and a 1.00 WHIP, the right-hander has been one of the most effective pitchers in baseball this year. Hendricks could continue his stellar season when he faces a Padres lineup that ranks last in the Majors in OPS vs. righties (.678) and second in total strikeouts (1,154).

Yu Darvish: With a 3.22 ERA and an 11.3 K/9 rate in his career, the right-hander has the potential to post a substantial DraftKings total when he gets a break from deep American League lineups and faces a Reds offense that ranks 19th in the Majors with a .724 OPS against righties.

Jose Fernandez: The owner of a 2.61 ERA and an 11.3 K/9 rate in the Majors, Fernandez has a skill set that is the envy of most big league hurlers. The right-hander could deliver a stellar start when he works at his pitcher-friendly home park against a Royals lineup that ranks last in baseball in ISO vs. righties (.127) and will work without the designated-hitter position at a National League venue.

Carlos Martinez: The right-hander could improve on his impressive ERA this year (3.24) when he works at his pitcher-friendly home park against a Mets lineup that ranks 24th in baseball in OPS vs. righties (.706) and 29th in total runs scored (469). Also worth noting: Martinez's chances of earning a win could be enhanced by a Cardinals bullpen that ranks fourth in the Majors with a 3.40 ERA.

All statistics are accurate through the completion of Monday's games.

Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.