The players listed below are in position to provide difference-making stats for DraftKings participants on Wednesday.
Anthony Rizzo: With 25 homers, 87 RBIs and a .399 on-base percentage across 531 plate appearances, the first baseman has been one of the most productive players in baseball this season. Rizzo could post a substantial DraftKings total when he brings his lifetime .229 ISO against right-handers (.186 vs. lefties) into a matchup with Padres righty Paul Clemens (career 5.32 ERA, 1.54 WHIP).
Addison Russell: The second-year shortstop will be in great position to improve on his lifetime 104 wRC+ against right-handers (77 vs. lefties) when he faces the right-handed Clemens (4.82 ERA, 1.58 WHIP in 2016) and a Padres bullpen that ranks 25th in baseball with a 4.40 ERA.
Jason Heyward: Hitting .225 with six homers across 413 at-bats this season, the outfielder could have a reduced price tag in DraftKings contests when he brings his solid lifetime .811 OPS against right-handers (.657 vs. lefties) into a matchup with the right-handed Clemens and an unreliable Padres bullpen. Heyward could be part of a productive lineup, as the Cubs rank third in baseball with 636 runs scored.
Miguel Cabrera: With a lifetime .322/.389/.562 slash line against right-handers, the first baseman has proven to be one of the best in baseball during those matchups. From the heart of a productive Tigers lineup, Cabrera could excel in a matchup against righty Tyler Duffey (career 4.97 ERA, 1.40 WHIP) and a Twins bullpen that ranks 22nd in baseball with a 4.25 ERA.
Cameron Maybin: With balanced career splits, the speedy outfielder could thrive against Duffey (5.93 ERA, 1.45 WHIP in 2016) and an unreliable Twins bullpen. Maybin could also swipe a base against catcher Kurt Suzuki, who sometimes struggles to thwart would-be basestealers.
Danny Espinosa: As a big leaguer, the shortstop has produced a .783 OPS against left-handers in comparison to a .665 mark vs. righties. On Wednesday, Espinosa could provide production at a premium position when he tangles with Orioles southpaw Wade Miley (career 4.17 ERA, 1.35 WHIP).
Jayson Werth: The outfielder has long fared best vs. left-handers, against whom he has a lifetime 149 wRC+ (113 vs. righties). As part of a Nats lineup that ranks fourth in the Majors with a .790 OPS against southpaws, Werth could reach base often or score multiple runs at the expense of the left-handed Miley (5.58 ERA, 1.43 WHIP in 2016).
Christian Yelich: Hitting .314 with 15 homers and 72 RBIs across 446 at-bats, the outfielder has been a major factor in many 2016 DraftKings contests. Yelich could reach base often or drive in multiple runs when he brings his lifetime .839 OPS against right-handers (.696 vs. lefties) into a matchup with Royals righty Dillon Gee (4.52 ERA, 1.52 WHIP in 2016).
Stephen Vogt: In his career, the catcher has logged a .768 OPS against right-handers in comparison to a .607 mark vs. lefties. Vogt could provide production at a premium position when he faces Indians righty Trevor Bauer (career 4.32 ERA, 1.36 WHIP).
Gregory Polanco: With a lifetime 112 wRC+ against right-handers (61 vs. lefties), the outfielder could collect multiple hits or RBIs when he faces Astros righty Collin McHugh (4.99 ERA, 1.52 WHIP in 2016). Polanco could also steal a base against catcher Jason Castro, who has thrown out seven of 37 would-be basestealers in 2016.
Nomar Mazara: The rookie outfielder will be in prime position to improve on his .297/.355/.473 slash line against right-handers when he faces rookie righty Tim Adleman (4.96 FIP, 1.40 WHIP) at offense-inducing Great American Ball Park. Mazara could also thrive late in the game against a Reds relief corps that ranks 29th in baseball with a 5.07 ERA.
Mitch Moreland: With a lifetime .206 ISO against right-handers (.140 vs. lefties), the first baseman could rip his 22nd round-tripper of the season or drive in multiple runs when he faces the inexperienced righty Adleman (24 1/3 innings) and an unreliable Reds bullpen at Cincy's homer-happy venue.
Zack Greinke: With a 4.21 ERA this season, the ace right-hander could have a reduced price tag in DraftKings contests when he faces a Braves lineup that ranks 29th in the Majors in ISO vs. righties (.132) and last in total home runs (88).
Kyle Hendricks: Having posted a 2.16 ERA and a 1.00 WHIP, the right-hander has been one of the most effective pitchers in baseball this year. Hendricks could continue his stellar season when he faces a Padres lineup that ranks last in the Majors in OPS vs. righties (.678) and second in total strikeouts (1,154).
Yu Darvish: With a 3.22 ERA and an 11.3 K/9 rate in his career, the right-hander has the potential to post a substantial DraftKings total when he gets a break from deep American League lineups and faces a Reds offense that ranks 19th in the Majors with a .724 OPS against righties.
Jose Fernandez: The owner of a 2.61 ERA and an 11.3 K/9 rate in the Majors, Fernandez has a skill set that is the envy of most big league hurlers. The right-hander could deliver a stellar start when he works at his pitcher-friendly home park against a Royals lineup that ranks last in baseball in ISO vs. righties (.127) and will work without the designated-hitter position at a National League venue.
Carlos Martinez: The right-hander could improve on his impressive ERA this year (3.24) when he works at his pitcher-friendly home park against a Mets lineup that ranks 24th in baseball in OPS vs. righties (.706) and 29th in total runs scored (469). Also worth noting: Martinez's chances of earning a win could be enhanced by a Cardinals bullpen that ranks fourth in the Majors with a 3.40 ERA.
All statistics are accurate through the completion of Monday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.