The players listed below are in position to provide difference-making stats for DraftKings participants on Wednesday.
Josh Donaldson: Since joining the Blue Jays at the outset of 2015, the third baseman has produced a lofty .311/.421/.603 slash line against left-handers. Donaldson could post a substantial DraftKings total when he bats at homer-happy Yankee Stadium against southpaw CC Sabathia (4.20 ERA, 1.38 WHIP in 2016).
Troy Tulowitzki: The shortstop could hit his 21st homer of the season or drive in multiple runs when he brings his lifetime .951 OPS against left-handers (.842 vs. righties) into a matchup at New York's hitter-friendly venue against the left-handed Sabathia. Since the outset of 2013, Sabathia has allowed right-handed hitters such as Tulowitzki to post an .816 OPS (.621 OPS allowed to lefty batters).
Evan Longoria: The third baseman has long fared best vs. left-handers against whom he has registered a lifetime .384 wOBA (.348 vs. righties). From the heart of the lineup, Longoria could excel in a matchup against the left-handed Christian Friedrich (4.84 ERA, 1.49 WHIP in 2016) and an unreliable Padres bullpen.
Paul Goldschmidt: With a lifetime .333/.435/.600 slash line against left-handers, the first baseman has proven to wield a potent bat in those matchups. Goldschmidt could put a ball into the outfield seats when he bats at his hitter-friendly home park against Mets southpaw Jonathon Niese (5.20 ERA, 1.58 WHIP in 2016).
Welington Castillo: With a lifetime .213 ISO against left-handers that exceeds his .149 mark vs. righties, the catcher will be poised to deliver at his offense-inducing home park against the left-handed Niese (career 4.04 ERA, 1.38 WHIP).
Anthony Rizzo: From the heart of a talent-laden Cubs lineup, the first baseman could produce a game-changing DraftKings total when he takes his lifetime .874 OPS against right-handers (.780 vs. lefties) into a matchup with righty Jimmy Nelson (4.07 ERA, 1.49 WHIP in 2016) and a Brewers bullpen that lacks reliable options after trading Jeremy Jeffress and Will Smith in late July.
Gregory Polanco: The outfielder owns notable lifetime splits, with a 114 wRC+ against right-handers in comparison to a 63 mark vs. lefties. With a versatile skill set that has led to 17 homers, 65 RBIs and 11 steals across 422 plate appearances this season, Polanco could contribute in multiple ways when he faces Giants righty Matt Cain (5.47 ERA, 1.57 WHIP in 2016).
Corey Seager: The shortstop will be primed to improve on his impressive lifetime .329/.383/.561 slash line against right-handers when he vacates his pitcher-friendly home venue and bats at offense-inducing Citizens Bank Park against rookie righty Jake Thompson (8.68 ERA, 1.50 WHIP).
Justin Turner: As a big leaguer, the third baseman has logged an .821 OPS against right-handers in comparison to a .710 mark vs. lefties. From the No. 3 spot in the Dodgers lineup, Turner could thrive at Philadelphia's hitter-friendly park against the inexperienced righty Thompson (9 1/3 innings) and a Phillies bullpen that ranks 24th in baseball with a 4.28 ERA.
Joey Votto: The first baseman has used an elite mix of power and patience to post an impressive lifetime .316/.436/.547 slash line against right-handers. With an overall .455/.552/.707 slash line since the All-Star break, Votto could reach base often when he bats at his hitter-friendly home park against Marlins righty Andrew Cashner (5.08 ERA, 1.44 WHIP in 2016).
Max Kepler: Kepler could continue his excellent rookie campaign (15 homers, 52 RBIs across 252 at-bats) when he brings his lifetime .911 OPS against right-handers (.639 vs. lefties) into a matchup with Braves righty Mike Foltynewicz (career 5.13 ERA, 1.48 WHIP). In his career, Foltynewicz has allowed left-handed hitters such as Kepler to post a .937 OPS (.762 OPS allowed to righty batters).
Scott Kazmir: With a 4.44 ERA this season, the left-hander could have a reasonable price tag in DraftKings contests when he faces a Phillies lineup that ranks 29th in the Majors with a .650 OPS against southpaws. Additionally, Kazmir's chances of earning a win could be well-supported by a Dodgers bullpen that ranks second in baseball with a 3.14 ERA.
Chris Archer: Having posted a 4.39 ERA and a 1.31 WHIP this season, the right-hander could have a reduced price tag in DraftKings contests when he works at his pitcher-friendly home park against a Padres lineup that ranks last in the Majors with a .678 OPS against righties.
Carlos Carrasco: With a 3.18 ERA, a 1.05 WHIP and a 9.7 K/9 rate since the outset of 2014, the right-hander has the skills to spin a gem when he faces a White Sox lineup that ranks 24th in the Majors with a .145 ISO against righties.
Yu Darvish: Having registered a 3.22 ERA and an 11.3 K/9 rate in his career, the right-hander has the potential to post an impactful DraftKings total when he faces an A's lineup that ranks 25th in the Majors with a .699 OPS against righties.
All statistics are accurate through the completion of Monday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.