Manager John Farrell is trying to combat that difficult stretch by mixing in more days off for his regulars. Shortstop Xander Bogaerts was able to get off his feet on Sunday, with Brock Holt starting at short. Jackie Bradley Jr. got a rest on Saturday.
Clubhouse report times have also been altered, along with the length of batting practice being shortened.
The original schedule had the Red Sox off Monday, but instead they will make a one-day trip to Cleveland to play a 1:10 p.m. ET makeup game for the postponement on April 7. After that, they go to Baltimore for two days.
• Red Sox 2016 schedule
Following a night game at Camden Yards on Wednesday comes the most challenging portion of this entire stretch -- a 1:10 p.m. ET first pitch in Detroit on Thursday. After four games there, it's off to Tropicana Field for a four-game set with the Rays, and then home for a six-day homestand.
The next off-day for the Red Sox is on Sept. 1, and they'll spend it in the Bay Area in preparation for a three-game series against the A's.
"Well, we've got an adjusted plan in place," Farrell said. "The schedule has been there, maybe with the exception of the makeup game [Monday] in Cleveland. That creates a quick turnaround. We've adjusted some things in our own schedule to accommodate the change -- the change in cities, the change in venues, the change in lineups. We've streamlined that some."
At a time when every game is crucial, the Red Sox are determined not to look for built-in excuses with the schedule.
"The most important thing is that we take care of the things that we can control," Farrell said. "We're not fretting about the schedule. We've known since January that this trip was coming. We look forward to it."
The skipper and his staff have been preparing for this stretch for some time.
"And after today, probably everybody has had a day off [recently]," Farrell said. "We've got to be a little bit more mindful right now. We've got heat to contend with, we've got consecutive games played to contend with, we've got a high number of games in season that guys have played."