The players listed below are in position to provide difference-making stats for DraftKings participants on Saturday.
Christian Yelich: Hitting .323 with a .393 on-base percentage, the outfielder could reach base often or display his power when he brings his lifetime .837 OPS against right-handers (.703 vs. lefties) into a matchup with White Sox fly-ball-prone righty James Shields (5.43 ERA, 1.7 HR/9 rate in 2016).
Jake Lamb: In his breakout 2016 season, the third baseman has produced an impressive .991 OPS against right-handers in comparison to a .665 mark vs. lefties. Lamb could have a great game when he faces Red Sox righty Clay Buchholz, who has a 6.31 ERA when working as a starter this season.
Mike Trout: With a lifetime .312/.402/.573 slash line against right-handers, the outfielder has proven to wield a potent bat during those matchups. Trout could put a ball into the outfield seats or reach base often when he faces Indians rookie righty Mike Clevinger (6.97 ERA, 1.79 WHIP).
Ian Desmond: In his bounceback 2016 season, the outfielder has produced a .973 OPS against left-handers in comparison to a .777 mark vs. righties. With 20 homers and 17 steals across 457 at-bats this year, Desmond will bring a diverse skill set into a matchup with Tigers southpaw Matt Boyd (career 6.13 ERA, 1.45 WHIP).
Daniel Murphy: With a .346 batting average, 21 homers and 82 RBIs across 405 at-bats, Murphy is in the midst of a career year. The second baseman could drive in multiple runs when he brings his lifetime .347 wOBA against right-handers (.306 vs. lefties) into a matchup with Braves rookie righty Rob Whalen (5.73 ERA).
Curtis Granderson: From his perch atop the lineup, the outfielder could produce a substantial DraftKings total when he brings his lifetime .368 wOBA against right-handers (.306 vs. lefties) into a matchup with righty Jarred Cosart (career 4.25 FIP, 1.41 WHIP) and a Padres relief corps that ranks 23rd in baseball with a 4.21 ERA.
Neil Walker: With a lifetime 121 wRC+ against right-handers that exceeds his 91 mark vs. lefties, the second baseman will be poised to produce when he tangles with the right-handed Cosart and a Padres squad that ranks 22nd in the Majors with a .683 defensive efficiency ratio.
Jay Bruce: The longtime Reds slugger could continue to make his mark in the Big Apple when he faces the righty Cosart (5.79 ERA, 1.86 WHIP in 2016) and an unreliable D-backs bullpen. In his career, Bruce has posted an .816 OPS against right-handers in comparison to a .721 mark vs. lefties.
Andrew Benintendi: The rookie outfielder could excel in a matchup with righty Archie Bradley (career 5.08 ERA, 1.54 WHIP) and a D-backs bullpen that ranks last in baseball with a 5.09 ERA. In his career, Bradley has allowed left-handed hitters such as Benintendi to post an .838 OPS (.730 OPS allowed to righty batters).
Travis Shaw: The third baseman will be in great position to improve on his lifetime .264/.335/.453 slash line against right-handers when he faces the right-handed Bradley (4.80 ERA, 1.51 WHIP in 2016) and an unreliable D-backs bullpen. Shaw could be part of a productive lineup, as the Red Sox lead the Majors with an .818 OPS against righties.
Eric Hosmer: Hitting .204 with two homers across 98 at-bats since the All-Star break, the first baseman could have a reduced price tag in DraftKings contests when he brings his lifetime 118 wRC+ against right-handers (88 vs. lefties) into a matchup with righty Tyler Duffey (career 4.90 ERA, 1.42 WHIP) and a Twins bullpen that ranks 25th in baseball with a 4.34 ERA.
Addison Russell: The second-year shortstop has produced notable lifetime splits, with a 103 wRC+ against right-handers in comparison to a 63 mark vs. lefties. Russell could provide production at a premium position when he faces Cardinals righty Luke Weaver, who will be making his big league debut.
Tyler Anderson: The rookie southpaw could improve on his impressive 3.04 ERA when he vacates his hitter-friendly home park and faces a Phillies lineup that ranks last in the Majors with a .647 OPS against lefties.
Adam Conley: The left-hander could spin a gem when he works at his pitcher-friendly home park against a White Sox lineup that ranks 21st in baseball with a .729 OPS against southpaws and will have to work without the designated-hitter position at a National League venue.
Jacob deGrom: With a lifetime 2.54 ERA and a 1.06 WHIP, the right-hander has the skills to post a game-changing DraftKings total when he works at home against a Padres lineup that ranks last in baseball in OPS vs. righties (.677) and third in total strikeouts (1,036).
Zach Davies: Having posted a 3.58 ERA and a 1.19 WHIP this season, the right-hander has become a trusted option for DraftKings participants. Davies could compile six-plus effective innings when he works at home against a Reds lineup that ranks 22nd in baseball in OPS vs. righties (.712) and 27th in OPS on the road (.683).
All statistics are accurate through the completion of Thursday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.