The players listed below are in position to provide difference-making stats for DraftKings participants on Friday.
Jose Altuve: With a lifetime .357/.407/.514 slash line against left-handers, the second baseman has proven to be one of the best in baseball during those matchups. Altuve has the plate skills to reach base often when he bats at hitter-friendly Rogers Centre against southpaw Francisco Liriano (5.34 ERA, 1.61 WHIP in 2016) and the speed to swipe a base against catcher Russell Martin, who has allowed more steals that all but seven catchers this season.
George Springer: Hitting leadoff, the outfielder may maximize his opportunities to reach base and score runs when he brings his lifetime 146 wRC+ against left-handers (111 vs. righties) into a matchup with the left-handed Liriano. In his career, Liriano has allowed right-handed hitters such as Springer to post a .719 OPS (.596 OPS allowed to lefty batters).
Daniel Murphy: With a .346 batting average, 21 homers and 82 RBIs across 405 at-bats, Murphy is in the midst of a career year. The second baseman could drive in multiple runs when he brings his lifetime .347 wOBA against right-handers (.306 vs. lefties) into a matchup with righty Mike Foltynewicz (4.37 ERA, 1.30 WHIP in 2016), who in his career has allowed left-handed hitters such as Murphy to post a .940 OPS (.766 OPS allowed to righty batters).
Xander Bogaerts: Hitting .315 with 80 runs and 69 RBIs across 503 plate appearances, the shortstop has been one of the most productive players at his position this season. From a premium spot in a Red Sox lineup that leads the Majors with 607 runs scored, Bogaerts could thrive when he brings his lifetime .368 wOBA against left-handers (.315 vs. righties) into a matchup with D-backs southpaw Patrick Corbin (5.37 ERA, 1.61 WHIP in 2016).
Dustin Pedroia: With a lifetime .842 OPS against left-handers that exceeds his .797 mark vs. righties, the second baseman will be poised to produce in a matchup against the southpaw Corbin. In his career, Corbin has allowed right-handed hitters such as Pedroia to post a .771 OPS (.676 OPS allowed to lefty batters).
Charlie Blackmon: Blackmon has long fared best vs. right-handers, against whom he has a lifetime .803 OPS (.752 vs. lefties). The outfielder could reach base often or score multiple runs when he bats at hitter-friendly Citizens Bank Park against rookie righty Jake Thompson, who allowed six runs across 4 1/3 innings in his big league debut on Aug. 6.
Curtis Granderson: From his perch atop the lineup, the outfielder could produce a substantial DraftKings total when he brings his lifetime 129 wRC+ against right-handers (88 vs. lefties) into a matchup with righty Paul Clemens (career 5.31 ERA, 1.51 WHIP) and a Padres relief corps that ranks 23rd in baseball with a 4.23 ERA.
Neil Walker: With a lifetime .180 ISO against right-handers that exceeds his .098 mark vs. lefties, the second baseman will be poised to deliver strong production when he tangles with the right-handed Clemens and a Padres squad that ranks 22nd in the Majors with a .683 defensive efficiency ratio.
Jay Bruce: The outfielder could display his power when he faces the rookie righty Clemens (4.61 ERA, 1.46 WHIP in 2016) and an unreliable Padres bullpen. In his career, Bruce has posted an .816 OPS against right-handers in comparison to a .721 mark vs. lefties.
Giancarlo Stanton: With a lifetime .288/.382/.611 slash line against left-handers, the outfielder has wielded a potent bat during those matchups. Stanton could put a ball into the outfield seats or reach base often when he faces White Sox southpaw Carlos Rodon (4.49 ERA, 1.51 WHIP in 2016).
Adeiny Hechavarria: Hitting .251 with three homers and one steal across 408 plate appearances this season, the shortstop could provide reasonably priced production when he brings his lifetime 87 wRC+ against left-handers (67 vs. righties) into a matchup with the left-handed Rodon (career 4.09 ERA, 1.47 WHIP).
Joey Votto: Votto has used an elite mix of power and patience to produce an impressive lifetime .315/.435/.545 slash line against right-handers. The first baseman could post a substantial DraftKings total when he bats at hitter-friendly Miller Park against right-hander Jimmy Nelson, who in his career has allowed left-handed hitters such as Votto to post an .829 OPS (.658 OPS allowed to righty batters).
Danny Valencia: With an impressive lifetime .884 OPS against left-handers (.674 vs. righties), the third baseman could excel against inexperienced Mariners southpaw Ariel Miranda (eight career innings).
Scooter Gennett: The second baseman owns pronounced lifetime splits, with a .335 wOBA against right-handers that exceeds his .221 mark vs. lefties. Gennett will be in prime position to excel when he bats at his offense-inducing home park against righty Homer Bailey and a Reds relief corps that ranks 29th in the Majors with a 5.09 ERA.
Kyle Gibson: With a 4.50 ERA and a 1.38 WHIP this season, the right-hander could have an econonical price tag in DraftKings contests when he tangles with a Royals lineup that ranks 29th in baseball in ISO vs. righties (.127) and 27th in total home runs (95).
Jon Gray: As a big leaguer, the right-hander has logged a 3.46 ERA on the road in comparison to a 5.74 mark at his hitter-friendly home park. Gray could thrive when he vacates Coors Field to face a Phillies lineup that ranks 28th in the Majors with a .692 OPS against righties.
Stephen Strasburg: With a 15-2 record, a 2.80 ERA and a 1.01 WHIP this season, the right-hander has the skills to post a game-changing DraftKings total when he works at home against a Braves lineup that ranks last in the Majors in ISO vs. righties (.123) and total home runs (74).
All statistics are accurate through the completion of Wednesday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.