The players listed below are in position to provide difference-making stats for DraftKings participants on Tuesday.
Josh Donaldson: Since joining the Blue Jays at the outset of 2015, the third baseman has produced a 1.022 OPS against left-handers (.940 vs. righties) and a 1.029 OPS at his hitter-friendly home park (.884 on the road). Donaldson could produce a game-changing DraftKings total when he hits at home against Rays fly-ball-prone southpaw Drew Smyly (5.14 ERA, 1.7 HR/9 rate in 2016).
Troy Tulowitzki: The shortstop has long fared best vs. left-handers, against whom he has posted a lifetime .403 wOBA (.364 vs. righties). Tulowitzki could provide production at a premium position when he faces the left-handed Smyly and a Rays relief corps that ranks 26th in the Majors with a 4.48 ERA.
Anthony Rizzo: Since the outset of 2015, the first baseman has produced a lofty .947 OPS against right-handers that exceeds his .870 mark vs. lefties. From the heart of a talent-laden Cubs lineup, Rizzo could go deep or drive in multiple runs when he faces Angels fly-ball-prone righty Jered Weaver (5.11 ERA, 1.7 HR/9 rate in 2016).
Addison Russell: The second-year shortstop will be in prime position to improve on his lifetime 103 wRC+ against right-handers (63 vs. lefties) when he tangles with the right-handed Weaver (4.85 ERA, 1.33 WHIP since the outset of 2015).
Jose Altuve: The second baseman will be in great position to add to his impressive 2016 totals of 19 homers, 80 runs and 25 steals across 500 plate appearances when he brings his impressive lifetime .354/.405/.513 slash line against left-handers into a matchup with southpaw Hector Santiago (career 4.63 FIP, 1.33 WHIP) and a Twins bullpen that ranks 23rd in baseball with a 4.26 ERA.
George Springer: As a big leaguer, the outfielder has logged a .239 ISO against left-handers in comparison to a .190 mark vs. righties. Hitting leadoff, Springer may maximize his opportunities to reach base and score runs at the expense of the left-handed Santiago (4.37 ERA, 1.34 WHIP in 2016) and a Twins squad that ranks 29th in baseball with a .670 defensive efficiency ratio.
Stephen Piscotty: With a lifetime .331/.416/.594 slash line against left-handers, the second-year outfielder is quickly becoming one of the best in baseball during those matchups. Piscotty could excel in a matchup against southpaw Brandon Finnegan (career 4.09 ERA, 1.31 WHIP) and a Reds relief corps that ranks 29th in baseball with a 5.06 ERA.
David Ortiz: Much of the slugger's memorable career has been built on a lofty lifetime .308 ISO against right-handers (.211 vs. lefties). Ortiz could display his power when he faces righty Luis Severino (6.02 ERA, 1.45 WHIP in 2016) and Yankees squad that dealt two of their best relievers (Aroldis Chapman and Andrew Miller) in late July.
Mookie Betts: With 23 homers, 74 RBIs, 86 runs and 18 steals across 508 plate appearances, the outfielder has been one of the most productive players in baseball this season. Betts could contribute in multiple ways when he faces a likely battery combination of Severino (career 4.17 ERA) and Brian McCann, who has allowed more steals than all but four catchers in 2016.
John Jaso: The first baseman could reach base often or score multiple runs when he brings his lifetime 123 wRC+ against right-handers (56 vs. lefties) into a matchup with rookie righty Luis Perdomo (6.67 ERA, 1.83 WHIP) and a Padres bullpen that ranks 24th in baseball with a 4.28 ERA.
Danny Valencia: The third baseman will be ready to rake when he brings his lifetime .381 wOBA against left-handers (.294 vs. righties) into a matchup with Orioles southpaw Wade Miley (5.08 ERA, 1.36 WHIP in 2016).
Scooter Gennett: The second baseman owns lopsided lifetime splits, with a 109 wRC+ against right-handers that exceeds his 28 mark vs. lefties. Gennett will be in prime position to excel when he bats at his offense-inducing home park against rookie righty Tyrell Jenkins (4.33 ERA, 1.67 WHIP) and a Braves bullpen that ranks 21st in baseball with a 4.04 ERA.
Kirk Nieuwenhuis: With 10 homers and eight steals across 298 plate appearances, the outfielder has the diverse skill set that interests DraftKings participants. Niewwenhuis could contribute in multiple ways when he brings his lifetime .740 OPS against right-handers (.478 vs. lefties) into a matchup against a likely battery combination of the rookie righty Jenkins (6.54 FIP) and catcher A.J. Pierzynski, who sometimes struggles to thwart would-be base stealers.
Freddie Freeman: The first baseman could thrive when he brings his lifetime .880 OPS against right-handers (.751 vs. lefties) into a matchup at hitter-friendly Miller Park against righty Wily Peralta. After posting a 6.68 ERA with the Brewers this season, the righty has logged a 6.31 mark across ten starts in Triple-A.
Marco Estrada: Having posted a 3.05 ERA and a 1.02 WHIP since joining the Blue Jays at the outset of 2015, the right-hander has become one of the most effective pitchers in the American League. Estrada could spin a gem when he faces a Rays lineup that ranks 21st in the Majors in OPS vs. righties (.714) and fourth in total strikeouts (993).
Kenta Maeda: In his first big league season, the right-hander has posted an impressive 3.22 ERA and a 1.07 WHIP. Maeda could continue his stellar debut when he works at his pitcher-friendly home park against a Phillies lineup that ranks 28th in the Majors with a .690 OPS vs. righties.
Chris Sale: With a lifetime 2.94 ERA and a 1.06 WHIP, the left-hander has the skills to post a substantial DraftKings total when he vacates his hitter-friendly home park and works at offense-suppressing Kauffman Stadium against a Royals lineup that ranks 22nd in baseball in ISO vs. lefties (.152) and 27th in total home runs (95).
All statistics are accurate through the completion of Sunday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.