Pedroia was walking around the Red Sox clubhouse after the game with a noticeable limp.
"He took a pretty severe hit off of the shin," Farrell said. "We will do whatever it takes to get to the bottom of it."
Aaron Hill, who started the game at third base, replaced Pedroia at second base. Travis Shaw replaced Hill at third.
Quinn Roberts is a reporter for MLB.com and covered the Red Sox on Friday. This story was not subject to the approval of Major League Baseball or its clubs.