The players listed below are in position to provide difference-making stats for DraftKings participants on Wednesday.
Bryce Harper: Since the outset of 2015, the outfielder has registered a lofty .299/.445/.597 slash line against right-handers. Harper may be worth a large investment in DraftKings contests when he bats at homer-happy Chase Field against righty Zack Godley (career 4.33 ERA, 1.37 WHIP) and a D-backs bullpen that ranks 29th in the Majors with a 4.98 ERA.
Daniel Murphy: Hitting .355 with 20 homers and 77 RBIs across 377 at-bats, the second baseman has been one of the most productive players at his premium position this season. Hitting behind Harper, Murphy could drive in multiple runs when he bats at Arizona's hitter-friendly park against Godley and a D-backs squad that ranks last in the Majors with a .666 defensive efficiency ratio.
Gregory Polanco: Having posted a lifetime 117 wRC+ against right-handers that exceeds his 58 mark vs. lefties, the outfielder will be in position to reach base often when he faces Braves righty Rob Whalen, who will be making his big league debut. Polanco could also swipe a base against catcher A.J. Pierzynski, who sometimes struggles to thwart would-be basestealers.
John Jaso: With a lifetime .347 wOBA against right-handers (.253 vs. lefties), the first baseman will be in prime position to reach base often and score multiple runs at the expense of the inexperienced righty Whalen and a Braves bullpen that ranks 21st in baseball with a 4.15 ERA.
Jason Kipnis: From the No. 2 spot in the lineup, Kipnis could excel when he brings his lifetime 126 wRC+ against right-handers (87 vs. lefties) into a matchup with righty Tyler Duffey (6.12 ERA, 1.54 WHIP in 2016) and a Twins bullpen that ranks 23rd in the Majors with a 4.30 ERA.
Tyler Naquin: The rookie outfielder will be in great position to improve on his impressive .337/.398/.635 slash line against right-handers when he meets up with the right-handed Duffey (career 4.94 ERA, 1.45 WHIP) and a Twins squad that ranks 29th in baseball with a .668 defensive efficiency ratio.
Lonnie Chisenhall: As a big leaguer, the outfielder has produced a 105 wRC+ vs. right-handers in comparison to an 83 mark vs. lefties. Chisenhall could be part of an Indians stack -- along with Kipnis, Naquin and outfielder Jose Ramirez -- against Duffey and an unreliable Twins bullpen.
Stephen Piscotty: With a lifetime .336/.424/.592 slash line against left-handers, the second-year outfielder is quickly becoming one of the best in baseball during those matchups. Piscotty could thrive when he vacates his pitcher-friendly home venue and visits homer-happy Great American Ball Park to take on rookie southpaw Cody Reed (7.07 ERA, 1.79 WHIP) and a Reds relief corps that ranks last in the Majors with a 5.21 ERA.
Scooter Gennett: The second baseman owns lopsided lifetime splits, with a 110 wRC+ against right-handers that exceeds his 29 mark vs. lefties. Gennett could provide cost-effective production at a premium position when he faces righty Edwin Jackson (career 4.60 ERA, 1.45 WHIP) and a Padres bullpen that ranks 24th in baseball with a 4.32 ERA.
Nomar Mazara: With a .350 wOBA against right-handers (.255 vs. lefties), the left-handed-hitting outfielder will be in great position to excel when he bats at hitter-friendly Camden Yards against righty Kevin Gausman (career 4.21 ERA, 1.29 WHIP). Also working in Mazara's favor: Baltimore's venue is especially power-inducing for left-handed batters.
Mitch Moreland: Hitting .366 with seven homers across 41 at-bats since July 18, the left-handed-hitting first baseman will bring a red-hot bat and a lifetime .207 ISO against right-handers (.135 vs. lefties) into a matchup with the right-handed Gausman (4.18 ERA, 1.32WHIP in 2016) at Baltimore's homer-happy venue.
Brandon Crawford: With balanced career splits, the shortstop could have a great game when he vacates his pitcher-friendly home stadium and bats at offense-inducing Citizens Bank Park against Aaron Nola (4.78 ERA, 1.31 WHIP in 2016). In his career, Nola has allowed left-handed hitters such as Crawford to post a .751 OPS (.676 OPS allowed to righty batters).
Stephen Vogt: With a lifetime 127 wRC+ against right-handers (49 vs. lefties), the catcher will be poised to provide production at a premium positon when he faces Angels righty Jered Weaver (5.14 ERA, 1.45 WHIP, 1.8 HR/9 rate in 2016).
Jeff Locke: With a 5.43 ERA and a 1.47 WHIP this season, the left-hander could have a reduced price tag in DraftKings contests when he works at pitcher-friendly Turner Field against a Braves lineup that ranks last in baseball in ISO vs. lefties (.104) and total home runs (65).
Steven Matz: The left-hander will be in position to improve on his lifetime 3.09 ERA when he faces a Yankees squad that ranks 26th in the Majors with a .694 OPS against southpaws. Matz could also see his chances of securing a win enhanced by a Mets bullpen that ranks fifth in baseball with a 3.24 ERA.
Johnny Cueto: With a 2.63 ERA and a 1.07 WHIP, the right-hander has been a major factor in many 2016 DraftKings contests. Cueto has the skills to spin a gem when he faces a Phillies lineup that ranks 28th in baseball with a .685 OPS against righties.
Junior Guerra: Having posted a 2.70 ERA and a 1.05 WHIP this season, the right-hander could be a productive second starter in DraftKings contests when he vacates his hitter-friendly home venue and works at pitcher-friendly Petco Park against a Padres lineup that ranks 29th in the Majors in OPS vs. righties (.674) and second in total strikeouts (981).
All statistics are accurate through the completion of Monday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.