The players listed below are in position to provide difference-making stats for DraftKings participants on Monday.
Jason Kipnis: From the No. 2 spot in an Indians lineup that ranks eight in the Majors with a .769 OPS against righties, Kipnis could excel when he brings his lifetime 127 wRC+ against right-handers (87 vs. lefties) into a matchup with righty Jose Berrios (10.20 ERA, 2.13 WHIP in four career starts) and a Twins bullpen that ranks 23rd in the Majors with a 4.32 ERA.
Tyler Naquin: The rookie outfielder will be in great position to improve on his impressive .337/.400/.645 slash line against right-handers when he meets up with the inexperienced Berrios and a Twins squad that ranks last in baseball with a .667 defensive efficiency ratio.
Lonnie Chisenhall: As a big leaguer, the outfielder has produced a 104 wRC+ vs. right-handers in comparison to an 84 mark vs. lefties. Chisenhall could be part of an Indians stack -- along with Kipnis, Naquin and outfielder Jose Ramirez -- against Berrios and an unreliable Twins bullpen.
Javier Baez: Eligible at second base and third base in DraftKings contests, Baez could be a desirable roster addition when he brings his lifetime .375 wOBA against left-handers (.273 vs. righties) into a matchup with Marlins southpaw Adam Conley (1.30 WHIP in 2016). He could be part of a productive lineup, as the Cubs rank fifth in the Majors with a .799 OPS against lefties.
Kris Bryant: During his powerful 2016 season (26 homers, 68 RBIs across 388 at-bats), the third baseman has posted an impressive 1.034 OPS against left-handers in comparison to an .895 mark vs. righties. From the heart of a talented Cubs lineup, Bryant could post a substantial DraftKings total when he faces the left-handed Conley (career 1.30 WHIP).
Bryce Harper: Since the outset of 2015, the outfielder has registered a lofty .298/.442/.598 slash line against right-handers. Harper may be worth a large investment in DraftKings contests when he bats at homer-happy Chase Field against righty Archie Bradley (career 4.67 ERA, 1.48 WHIP) and a D-backs bullpen that ranks 28th in the Majors with a 4.73 ERA.
Franklin Gutierrez: The outfielder has produced pronounced lifetime splits, with a .206 ISO against left-handers in comparison to a .123 mark vs. righties. Gutierrez could be a cost-effective option in DraftKings contests when he tangles with Red Sox southpaw Eduardo Rodriguez (6.51 ERA, 1.62 WHIP in 2016).
Chris Iannetta: The catcher has long fared best vs. left-handers, against whom he has logged a lifetime .851 OPS (.704 vs. righties). Iannetta could provide cost-effective production at a premium position when he faces the left-handed Rodriguez (career 4.59 ERA, 1.38 WHIP).
Nelson Cruz: The only player in the Majors to hit 40 homers in each of the previous two seasons, Cruz owns an impressive lifetime 146 wRC+ against left-handers (118 vs. righties). From the heart of the lineup, the outfielder could go deep or drive in multiple runs when he faces the left-handed Rodriguez (career 4.52 FIP).
Xander Bogaerts: Hitting .329 with 66 RBIs and 78 runs across 463 plate appearances, the shortstop has been one of the most productive players in the American League this season. From the No. 3 spot in a Red Sox lineup that leads the Majors with 569 runs scored, Bogaerts could post a substantial DraftKings total when he brings his lifetime .863 OPS against left-handers (.724 vs. righties) into a matchup with Mariners southpaw James Paxton (career 1.32 WHIP).
Dustin Pedroia: The second baseman could reach base often and score multiple runs when he bats out of the No. 2 spot in a potent Red Sox lineup against the left-handed Paxton (4.27 ERA, 1.50 WHIP in 2016). In his career, Pedroia has posted a 127 wRC+ against left-handers in comparison to a 113 mark vs. righties.
Logan Verrett: With a 4.12 ERA and a 1.41 WHIP this season, the right-hander could have a reasonable cost in DraftKings contests when he works at home against a Yankees squad that will have to play without the designated hitter spot at a National League venue. The Bronx Bombers are tied for 24th in baseball in OPS against right-handers (.703) and rank 28th in OPS on the road (.675).
Danny Salazar: Having posted a 3.27 ERA and a 9.7 K/9 rate since the outset of 2015, the right-hander has the skills to spin a gem when he works at home against a Twins lineup that ranks 19th in the Majors with a .719 OPS against righties. Salazar could also pick up a win if his supporting cast can improve on their impressive .769 OPS against righties at the expense of Berrios.
Jimmy Nelson: With a 4.79 FIP and a 1.40 WHIP this season, the right-hander could have a reduced price tag in DraftKings contests when he vacates his hitter-friendly home park and works at pitcher-friendly Petco Park against a Padres lineup that ranks 29th in the Majors in OPS vs. righties (.672) and second in total strikeouts (962).
Stephen Strasburg: Arguably the most talented hurler on the Monday docket, the right-hander could post a substantial DraftKings total when he brings his impressive season-to-date 2.68 ERA, 0.99 WHIP and 10.9 K/9 rate into a matchup with a D-backs squad that excels against southpaws but is tied for 18th in the Majors with a .156 ISO against righties.
All statistics are accurate through the completion of Saturday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB. This story was not subject to the approval of Major League Baseball or its clubs.