The players listed below are in position to provide difference-making stats for DraftKings participants on Saturday.
Mike Napoli: With 22 homers across 355 at-bats, the outfielder has been one of the most powerful players in the American League this season. Napoli could go deep or drive in multiple runs when he brings his lifetime .910 OPS vs. left-handers (.803 vs. righties) into a matchup with A's rookie southpaw Dillon Overton (8.40 ERA, 1.93 WHIP in three starts).
Francisco Lindor: Hitting .306 with 12 homers, 68 runs and 13 steals across 431 plate appearances, the second-year shortstop has been one of the most productive players at his premium position this season. From the No. 3 spot in a productive Indians lineup, Lindor could excel when he brings his lifetime 134 wRC+ against left-handers (119 vs. righties) into a matchup with the inexperienced lefty Overton (15 career innings).
Justin Turner: Hitting .327 with 15 homers across 165 at-bats since June 7, the third baseman will bring a red-hot bat and a lifetime .822 OPS against right-handers (.699 vs. lefties) into a matchup with rookie righty Braden Shipley (one career start) and a D-backs squad that ranks 29th in baseball with a .670 defensive efficiency ratio.
Adrian Gonzalez: With nine homers across 360 at-bats this season, the first baseman could have a reduced price tag in DraftKings contests when he brings his lifetime .224 ISO against right-handers (.156 vs. lefties) into a matchup with the inexperienced righty Shipley and a D-backs bullpen that ranks 27th in the Majors with a 4.62 ERA.
Bryce Harper: Since the outset of last season, the outfielder has produced a lofty .300/.444/.602 slash line against right-handers. Harper may be worth a major investment in DraftKings contests when he faces the right-handed Jake Peavy, who has a 4.41 FIP in 2016.
Wilmer Flores: With a lifetime .780 OPS against left-handers that exceeds his .665 mark vs. righties, the third baseman could excel against southpaw Jorge De La Rosa (5.70 ERA, 1.62 WHIP in 2016) and a Rockies squad that ranks 28th in the Majors with a .673 defensive efficiency ratio. In his career, De La Rosa has allowed right-handed hitters such as Flores to post a .797 OPS (.646 OPS allowed to lefty batters).
Zack Cozart: Hitting leadoff, the shortstop may maximize his opportunities to reach base and score runs when he takes his lifetime .736 OPS against left-handers (.660 vs. righties) into a matchup with southpaw Christian Friedrich (career 5.58 ERA, 1.60 WHIP) and a Padres bullpen that ranks 24th in baseball with a 4.44 ERA.
Brandon Phillips: With a lifetime 108 wRC+ against left-handers in comparison to a 90 mark vs. righties, the second baseman will be poised to deliver when he meets up with the left-handed Friedrich (5.00 ERA, 1.60 WHIP in 2016) and a Padres squad that ranks 23rd in the Majors with a .681 defensive efficiency ratio.
Miguel Cabrera: With a lifetime .322/.390/.564 slash line against right-handers, the first baseman has proven to be one of the best in baseball during those matchups. Cabrera could go deep or drive in multiple runs when he tangles with Astros righty Mike Fiers (4.69 ERA, 1.38 WHIP in 2016).
Javier Baez: Eligible at second base and third base in DraftKings contests, Baez could be a desirable roster addition when he brings his lifetime .379 wOBA against left-handers (.272 vs. righties) into a matchup with Mariners southpaw Wade Miley (5.23 ERA, 1.42 WHIP in 2016). Baez may be one of several to excel out of the Cubs lineup, which leads the Majors with an .811 OPS against lefties.
Gregory Polanco: The outfielder owns pronounced lifetime splits, with a 117 wRC+ against right-handers in comparison to a 55 mark vs. lefties. Polanco has the plate skills to excel against Brewers righty Chase Anderson (5.40 ERA, 1.45 WHIP in 2016) and the speed to swipe a base against Jonathan Lucroy, who has allowed more steals than all but one catcher in 2016.
Dioner Navarro: The catcher has long fared best vs. left-handers, against whom he has a lifetime .767 OPS (.652 vs. righties). Hitting .199 this season, Navarro could be a cost-effective source of production when he faces lefty Tommy Milone (4.97 ERA, 1.49 WHIP in 2016) and a Twins squad that ranks last in baseball with a .667 defensive efficiency ratio.
Josh Tomlin: With a 3.48 ERA and a 1.11 WHIP, the right-hander has been a productive member of many 2016 DraftKings squads. Tomlin could continue his strong season when he works at home against an A's lineup that ranks 26th in the Majors with a .702 OPS against righties.
Nathan Eovaldi: With a 4.80 ERA this season, the right-hander could have a reasonable price tag in DraftKings contests when he vacates his hitter-friendly home park and works at offense-suppressing Tropicana Field against a Rays lineup that ranks 25th in baseball with a .702 OPS against righties.
Julio Teheran: The right-handed Braves hurler will be in great position to improve on his 2.71 ERA and 0.96 WHIP this season when he works at his offense-suppressing home park against a Phillies lineup that ranks 28th in the Majors with a .689 OPS against righties.
Jake Arrieta: Arguably the most accomplished pitcher on the Saturday slate, Arrieta could deliver a stellar start when he works at home against a Mariners lineup that will have to play without the designated-hitter position. Also working in Arrieta's favor: The Cubs lead the Majors by a wide margin with a .731 defensive efficiency ratio.
All statistics are accurate through the completion of Thursday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.