The players listed below are in position to provide difference-making stats for DraftKings participants on Thursday.
David Ortiz: One of the most feared hitters of his generation, Ortiz owns a lifetime .309 ISO against right-handers that exceeds his .212 mark vs. lefties. The slugger will be in great position to hit his 26th homer of the season when he faces Angels fly-ball-prone righty Jered Weaver (1.9 HR/9 rate in 2016).
Mookie Betts: With 20 homers, 64 RBIs, 80 runs and 16 steals across 453 plate appearances, the outfielder has been one of the most productive players in baseball this season. Hitting leadoff in a lineup that leads the Majors by a wide margin with an .835 OPS against right-handers, Betts could score multiple runs when he faces the right-handed Weaver (5.32 ERA, 1.45 WHIP in 2016).
Travis Shaw: The third baseman will be in great position to improve on his lifetime .269/.341/.462 slash line against right-handers when he faces the righty Weaver, who has a 4.92 ERA and a 1.6 HR/9 rate since the outset of last season.
Brock Holt: This season, the outfielder has registered a .788 OPS against right-handers that exceeds his .410 mark vs. lefties. As part of a Red Sox lineup that leads the Majors with 557 runs scored, Holt could reach base often or score multiple runs when he faces the right-handed Weaver.
Chris Davis: Since the outset of 2013, the first baseman has used an elite combination of power and patience to post a .934 OPS against right-handers (.757 vs. lefties). Davis could put a ball into the outfield seats or drive in multiple runs when he faces right-hander Kyle Gibson (career 4.46 ERA, 1.36 WHIP) and a Twins bullpen that ranks 24th in the Majors with a 4.41 ERA.
Jonathan Schoop: With 17 homers across 376 at-bats this season, the second baseman ranks among the most powerful players at his premium position. Schoop could improve on his lifetime .772 OPS against right-handers (.612 vs. lefties) when he meets up with the right-handed Gibson (4.67 ERA, 1.39 WHIP in 2016) and a Twins squad that ranks 29th in baseball with a .669 defensive efficiency ratio.
Pedro Alvarez: Alvarez owns notable lifetime splits, with a 117 wRC+ against right-handers that exceeds his 64 mark vs. lefties. The slugger could display his power when he faces the right-handed Gibson, who in his career has allowed left-handed hitters such as Alvarez to post a .734 OPS (.697 OPS allowed to righty batters).
Manny Machado: Hitting .312 with 20 homers across 382 at-bats, Machado is in the midst of a spectacular follow-up to his breakout 2015 season. Eligible at third base and shortstop in DraftKings contests, he could continue his stellar campaign when he faces Gibson (career 4.06 FIP) and an unreliable Twins bullpen.
Ryan Braun: With a lifetime .337/.405/.624 slash line against left-handers, the outfielder has been one of the best in baseball during those matchups. Braun could post a substantial DraftKings total when he bats at his offense-inducing home park against southpaw Robbie Ray (career 4.44 ERA, 1.46 WHIP) and a D-backs bullpen that ranks 27th in the Majors with a 4.65 ERA.
Jonathan Lucroy: With a lifetime .833 OPS against left-handers in comparison to a .762 mark vs. righties, the catcher could provide stellar production when he faces the southpaw Ray (4.53 ERA, 1.51 WHIP in 2016) and a D-backs squad that ranks last in the Majors with a .669 defensive efficiency ratio. In his career, Ray has allowed right-handed hitters such as Lucroy to post a .799 OPS (.751 OPS allowed to lefty batters).
Nomar Mazara: The rookie outfielder will be in prime position to improve on his .296/.354/.468 slash line against right-handers when he bats at his hitter-friendly home park against Royals righty Yordano Ventura (4.99 ERA, 1.41 WHIP in 2016).
Mitch Moreland: Hitting .230 this season, the first baseman could have a reduced price tag in DraftKings contests when he brings his lifetime .202 ISO against right-handers (.135 ISO vs. lefties) into a matchup at his offense-inducing home park vs. the right-handed Ventura (4.71 FIP in 2016).
Jurickson Profar: Eligible at second base and third base in DraftKings contests, Profar could be a productive DraftKings addition when he brings his lifetime .757 OPS against right-handers (.508 vs. lefties) into a home matchup against the right-handed Ventura (career 1.32 WHIP).
Odubel Herrera: The outfielder will be in position to reach base often and score multiple runs when he brings his lifetime .351 wOBA against right-handers (.295 vs. lefties) into a matchup with Braves righty Matt Wisler. In his career, Wisler has allowed left-handed hitters such as Herrera to post an .886 OPS (.683 OPS allowed to righty batters).
Max Kepler: With seven homers and 21 RBIs across 80 at-bats in July, the outfielder has been a cost-effective option in many recent DraftKings contests. Kepler could continue to rake when he brings his lifetime .821 OPS against right-handers (.706 vs. lefties) into a matchup with Orioles righty Ubaldo Jimenez (7.38 ERA, 1.97 WHIP in 2016).
Johnny Cueto: Having posted a 2.53 ERA and a 1.03 WHIP, the right-hander has been one of the most effective starters in the National League this season. Cueto could spin a gem when he works at his pitcher-friendly home park against a Nationals lineup that ranks 16th in the Majors with a .732 OPS against righties.
Aaron Nola: With a 10.61 ERA and a 2.04 WHIP across his past seven starts, the right-hander could have a reduced price tag in DraftKings contests when he works at pitcher-friendly Turner Field against a Braves lineup that ranks last in baseball in ISO vs. right-handers (.117) and total home runs (62).
All statistics are accurate through the completion of Tuesday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.