The players listed below are in position to provide difference-making stats for DraftKings participants tonight.
Mark Trumbo: With 30 homers and 73 RBIs across 381 at-bats, the outfielder has been one of the most productive players in baseball this season. Trumbo could go deep or drive in multiple runs when he takes his lifetime .815 OPS against left-handers (.762 vs. righties) into a matchup with the left-handed Jorge De La Rosa (6.07 ERA, 1.67 WHIP in 2016) and a Rockies relief corps that ranks 29th in baseball with a 4.96 ERA.
J.J. Hardy: The shortstop could have a great game when he brings his lifetime .763 OPS against left-handers (.705 vs. righties) into a matchup with the left-handed De La Rosa and a Rockies squad that ranks 29th in baseball with a .670 defensive efficiency ratio. In his career, De La Rosa has allowed right-handed hitters such as Hardy to post a .798 OPS (.647 OPS allowed to lefty batters).
Edwin Encarnacion: Having produced 26 homers and a Major League-leading 86 RBIs this season, Encarnacion has been a terrific DraftKings choice on many occasions. With a .914 OPS vs. righties since the outset of 2012, the slugger is primed for another big performance when he faces righty Colin Rea (career 4.82 ERA) and a Padres bullpen that ranks 25th in baseball with a 4.51 ERA.
Michael Saunders: Having already tied a career high with 19 homers and recorded a .288 average -- also a personal best -- Saunders has bounced back well from an injury-plagued 2015 season in which he played only nine games. The outfielder could have success when he takes his lifetime .730 OPS vs. righties (.695 vs. lefties) into a matchup with the righty Rea (5.01 ERA in 2016) and a suspect Padres relief corps.
Anthony Rizzo: With 24 homers, 72 RBIs and a .397 on-base percentage, the first baseman has been one of the most productive players in baseball this season. Rizzo could go deep or drive in multiple runs when he bats at hitter-friendly U.S. Cellular Field against fly-ball-prone righty Miguel Gonzalez (career 1.3 HR/9 rate).
Jason Heyward: Hitting .231 this season, the outfielder could have a reduced price tag in DraftKings contests when he brings his lifetime .818 OPS against right-handers (.659 vs. lefties) into a matchup with the right-handed Gonzalez (career 4.62 FIP).
Carlos Gonzalez: As a big leaguer, the outfielder has logged a lofty .935 OPS against right-handers that exceeds his .749 mark vs. lefties. CarGo could add to his impressive 2016 totals of 20 homers and 60 RBIs across 365 at-bats when he bats at hitter-friendly Camden Yards against Orioles righty Yovani Gallardo (5.69 ERA, 1.70 WHIP in 2016).
Charlie Blackmon: Batting leadoff, Blackmon could maximize his opportunities to contribute when he takes his career .802 OPS vs. righties (.729 vs. lefties) into a matchup with the right-handed Gallardo at homer-happy Camden Yards.
Mike Trout: The outfielder will be in prime position to post a difference-making DraftKings total when he brings his lofty lifetime .312/.400/.572 slash line against right-handers into a matchup with Royals righty Ian Kennedy (4.28 ERA, 2.1 HR/9 in 2016).
Albert Pujols: Hitting behind Trout (career .400 on-base percentage), the first baseman could drive in multiple runs when he brings his impressive lifetime .308/.391/.566 slash line against right-handers into a matchup with the righty Kennedy.
Jake Lamb: Hitting .288 with 21 homers and 65 RBIs across 316 at-bats, the third baseman has been one of this season's breakout performers. Lamb could stay hot when he takes his lifetime .846 OPS against right-handers (.604 vs. lefties) into a matchup at hitter-friendly Miller Park against righty Chase Anderson (career 4.51 ERA, 1.36 WHIP).
Marcus Semien: The shortstop has been among the most powerful players at his premium position this season, hitting 20 homers in 337 at-bats. The right-handed-swinging Semien could produce when he takes his lifetime .854 OPS vs. lefties (.660 vs. righties) into a matchup with Rangers southpaw Martin Perez, who has yielded a .778 OPS to right-handed hitters during his big league tenure.
Aaron Sanchez: With a 2.87 ERA and a 1.17 WHIP, the right-hander has emerged as a reliable option for DraftKings participants this season. Sanchez could spin a gem when he faces a Padres lineup that ranks 29th in baseball with a .670 OPS against righties.
Jake Arrieta: With a 2.34 ERA and a 0.97 WHIP since joining the Cubs during the 2013 season, the right-hander has proven to be one of the most effective starters in baseball. Arrieta could continue to limit the opposition when he faces a White Sox lineup that ranks 25th in the Majors with a .703 OPS against righties.
Jake Peavy: Since the outset of 2015, Peavy has posted a 3.47 ERA at his pitcher-friendly home park in comparison to a 5.33 mark on the road. The right-hander could be a cost-effective second starter in DraftKings contests when he works at home against a Reds lineup that ranks 26th in baseball in both OPS vs. righties (.697) and OPS on the road (.683).
All statistics are accurate through the completion of Saturday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB. This story was not subject to the approval of Major League Baseball or its clubs.