The players listed below are in position to provide difference-making stats for DraftKings participants on Friday.
David Ortiz: In his prolific career, the slugger has produced an impressive .295/.398/.585 slash line against right-handers. Leading the American League with a .326 batting average, Ortiz could collect multiple hits or RBIs at the expense of righty Kyle Gibson (career 4.52 ERA, 1.37 WHIP) and a Twins bullpen that ranks 23rd in baseball with a 4.36 ERA.
Mookie Betts: The outfielder could add to his impressive 2016 totals of 18 homers, 75 runs and 60 RBIs across 436 plate appearances when he brings balanced lifetime splits into a matchup with the right-handed Gibson (5.12 ERA, 1.52 WHIP in 2016) and a Twins squad that ranks 29th in baseball with a .670 defensive efficiency ratio. Betts could also steal his 17th base of the season against catcher Kurt Suzuki, who sometimes struggles to thwart would-be base stealers.
Travis Shaw: The third baseman will be in position to improve on his lifetime .267/.341/.464 slash line against right-handers when he faces the right-handed Gibson, who in his career has allowed left-handed batters such as Shaw to post a .744 OPS (.698 OPS allowed to righty batters).
Josh Donaldson: Since joining the Blue Jays at the outset of 2015, the third baseman has posted a game-changing .320/.429/.631 slash line against left-handers and a .331/.415/.642 slash line at his hitter-friendly home park. Donaldson could post a substantial DraftKings total when he hits at home against Mariners southpaw James Paxton (4.56 ERA, 1.63 WHIP in 2016).
Troy Tulowitzki: With an impressive lifetime .315/.399/.549 slash line against left-handers, the shortstop will be in great position to rip his 17th round-tripper of the season when he bats at his offense-inducing home park against the left-handed Paxton.
Jake Lamb: Hitting .294 with 21 homers and 65 RBIs across 309 at-bats, the third baseman is in the midst of a breakout season. Lamb could stay hot when he brings his lifetime .854 OPS against right-handers (.604 vs. lefties) into a matchup at hitter-friendly Great American Ball Park against righty Dan Straily (career 4.44 ERA) and a Reds relief corps that ranks last in baseball with a 5.47ERA.
Miguel Cabrera: With a lifetime .322/.389/.562 slash line against right-handers, the first baseman has proven to be one of the best in baseball during those matchups. Cabrera could display his power when he bats at homer-happy U.S. Cellular Field against righty Jacob Turner (career 5.14 ERA, 1.48 WHIP).
Gregory Polanco: The outfielder owns pronounced career splits, with a .780 OPS against right-handers in comparison to a .557 mark vs. lefties. From a premium lineup spot, Polanco could thrive when he faces rookie righty Zach Eflin (4.14 ERA) and a Phillies bullpen that ranks 22nd in the Majors with 4.33 ERA.
Joey Votto: The first baseman has used an elite mix of power and patience to build an impressive lifetime .314/.434/.544 slash line against right-handers. Votto could go deep or reach base often when he bats at his hitter-friendly home park against D-backs righty Archie Bradley (career 4.85 ERA, 1.49 WHIP) and a D-backs bullpen that ranks 26th in baseball with a 4.53 ERA.
Jay Bruce: In his career, the outfielder has registered an .815 OPS against right-handers in comparison to a .718 mark vs. lefties. Bruce could post a substantial DraftKings total when he bats at his offense-inducing home park against the right-handed Bradley (4.37 ERA, 1.41 WHIP in 2016) and a D-backs squad that ranks 28th in baseball with a .672 defensive efficiency ratio.
Christian Yelich: Hitting .317 with a .395 on-base percentage this season, the outfielder has the skills to reach base often when he takes his lifetime .827 OPS against right-handers (.699 vs. lefties) into a matchup with Mets righty Logan Verrett. The right-handed hurler owns a lifetime 4.60 ERA when working as a starter (3.18 ERA as a reliever).
Freddie Freeman: The first baseman has long fared best vs. right-handers, against whom he has a lifetime .878 OPS (.751 vs. lefties). Freeman could excel when he vacates his pitcher-friendly home park and bats at homer-happy Coors Field against righty Jon Gray (career 4.69 ERA, 1.31 WHIP) and a Rockies relief corps that ranks 28th in the Majors with a 4.93 ERA.
Jason Kipnis: The second baseman could reach base often or score multiple runs when he brings his lifetime .822 OPS against right-handers (.661 vs. lefties) into a matchup at hitter-friendly Camden Yards against righty Dylan Bundy, who owns a lifetime 1.60 WHIP and will be making his second career start.
Madison Bumgarner: With a 2.12 ERA and a 0.98 WHIP this season, the left-hander continues to rank among the most dominant aces in baseball. Bumgarner could spin a gem when he faces a Yankees lineup that ranks 27th in the Majors with a .704 OPS against southpaws.
Michael Fulmer: Having posted a 0.83 ERA and a 0.81 WHIP across his past 10 starts, the right-hander has been a major asset in many recent DraftKings contests. Fulmer could continue his outstanding rookie season when he faces a White Sox lineup that ranks 25th in the Majors with a .704 OPS against righties.
Matt Shoemaker: With an 88-to-9 strikeout-to-walk ratio across his past 11 starts, the right-hander ranks among the hottest hurlers in baseball. Shoemaker could compile a handful of effective innings and strikeouts when he faces an Astros lineup that ranks second in the Majors with 878 whiffs.
All statistics are accurate through the completion of Wednesday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.