The players listed below are in position to provide difference-making stats for DraftKings participants on Friday.
Joey Votto: The first baseman has used a patient, powerful approach to build an impressive lifetime .314/.433/.543 slash line against right-handers. Votto could go deep or drive in multiple runs when he bats at his homer-happy venue against Brewers righty Matt Garza (5.62 ERA, 1.60 WHIP since the outset of 2015).
Jay Bruce: The outfielder has long fared best vs. right-handers, against whom he has a lifetime .815 OPS (.720 vs. lefties). Bruce could add to his impressive 2016 totals of 18 homers and 63 RBIs across 318 at-bats when he bats at his hitter-friendly home park against the right-handed Garza (5.54 ERA, 1.77 WHIP in 2016).
Adam Duvall: With 23 homers and 61 RBIs across 301 at-bats, the outfielder has been a major contributor to many 2016 DraftKings squads. The Home Run Derby participant could continue his powerful campaign when he brings his lifetime .829 OPS against right-handers (.684 vs. lefties) into a matchup at his offense-inducing home park against the right-handed Garza.
Jake Lamb: Hitting .291 with 20 homers and 61 RBIs across 289 at-bats, Lamb is in the midst of a breakout season. The third baseman could post a notable DraftKings total when he works at his hitter-friendly home park against Dodgers righty Bud Norris, who in his career has allowed left-handed hitters such as Lamb to post an .811 OPS (.701 OPS allowed to righty batters).
Mike Trout: With a lifetime .312/.400/.573 slash line against right-handers, the outfielder has proven to wield a potent bat during those matchups. Trout has the plate skills to thrive against White Sox fly-ball-prone righty Miguel Gonzalez (career 4.66 FIP, 1.30 WHIP, 1.3 HR/9 rate) and the speed to swipe a base against catcher Dioner Navarro, who sometimes struggles to thwart would-be base stealers.
Kole Calhoun: With a lifetime .773 OPS against right-handers that exceeds his .738 mark vs. lefties, the outfielder will be poised to rip a round-tripper or drive in multiple runs when he tangles with the right-handed Gonzalez (4.39 ERA, 1.39 WHIP in 2016).
Dioner Navarro: As a big leaguer, the catcher has produced a .768 OPS against left-handers that exceeds his .656 mark vs. righties. The switch-hitting Navarro could excel when he bats from the right side against Angels lefty Hector Santiago, who in his career has allowed right-handed hitters to post a .752 OPS (.627 OPS allowed to lefty batters).
Carlos Beltran: With balanced lifetime splits that include a .283/.347/.511 slash line against left-handers, the outfielder will be poised to hit his 20th homer of the season when he bats at his hitter-friendly home park against Red Sox southpaw Eduardo Rodriguez (8.59 ERA, 1.74 WHIP in 2016).
Starlin Castro: In his career, the second baseman has logged a .756 OPS against left-handers that exceeds his .711 mark vs. righties. Set to bat at his offense-inducing home park, Castro could provide production at a premium position when he faces the left-handed Rodriguez (career 4.77 ERA, 1.38 WHIP).
Jason Kipnis: From a premium lineup spot, the second baseman could reach base often or drive in multiple runs when he brings his lifetime .818 OPS against right-handers (.659 vs. lefties) into a matchup with righty Ervin Santana (career 4.16 ERA, 1.28 WHIP) and a Twins bullpen that ranks 25th in the Majors with a 4.51 ERA.
Tyler Naquin: The rookie outfielder will be in great position to improve on his impressive .324/.382/.604 slash line against right-handers when he faces the right-handed Santana (4.06 ERA, 1.29 WHIP in 2016) and a Twins squad that ranks last in the Majors with a .665 defensive efficiency ratio.
Miguel Cabrera: With a lifetime .322/.389/.563 slash line against right-handers, the first baseman has proven to be one of the best in baseball during those matchups. Cabrera could put a ball into the outfield seats when he faces Royals fly-ball-prone righty Ian Kennedy (5.05 FIP, 1.9 HR/9 rate in 2016).
Brandon Crawford: With balanced career splits, the shortstop could succeed against righty Andrew Cashner (5.40 ERA, 1.56 WHIP in 2016) and a Padres bullpen that ranks 23rd in the Majors with a 4.42 ERA. In his career, Cashner has allowed left-handed hitters such as Crawford to post a .760 OPS (.668 OPS allowed to righty batters).
Anthony DeSclafani: Since returning from a season-opening stint on the disabled list, DeSclafani has posted a 2.23 ERA across six starts. The right-hander could compile a handful of effective innings and whiffs when he faces a Brewers lineup that leads the Majors with 833 strikeouts.
Jorge De La Rosa: With a 4.61 ERA and a 1.44 WHIP in the Majors, the left-hander could be a cost-effective second starter in DraftKings contests when he vacates his hitter-friendly home park and works at offense-suppressing Turner Field against a Braves lineup that ranks 29th in the Majors with a .640 OPS against southpaws.
Carlos Carrasco: With a 3.04 ERA, a 1.05 WHIP and a 9.9 K/9 rate since the outset of 2014, the right-hander has the skills to spin a gem when he faces a Twins lineup that ranks 18th in the Majors with a .725 OPS against righties. Carrasco could also pick up a win if his supporting cast has success against Santana and a shaky Twins bullpen.
Bartolo Colon: Having posted a 3.28 ERA and 1.22 WHIP, the right-hander has been a cost-effective option in many 2016 DraftKings contests. Colon could continue his solid season when he faces a Phillies lineup that ranks 25th in the Majors with a .707 OPS against righties.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.