On an RBI single in the third inning, Holliday came up limping after rounding first base. Appearing to favor his left ankle, he limped back to first base and received attention from the St. Louis medical staff. Holliday, batting .241 with 15 home runs and 52 RBIs, remained in and struck out in the top of the seventh before exiting before the bottom half. Tommy Pham replaced him in left. Manager Mike Matheny said Holliday is day to day with a twisted ankle.
"He twisted his ankle rounding first base and it tightened up on him as the game went on," Matheny said.
In the seventh, a 103-mph liner (per Statcast™) hit by Jonathan Villar caromed off Wacha's right heel and the right-hander went to the ground, the sound of the play audible throughout the stadium. Third baseman Greg Garcia recovered to retire Villar at first on a barehand play, but Wacha was unable to continue after 6 2/3 innings. Matt Bowman came in to replace Wacha.
Wacha officially suffered a bruised right heel, but told reporters after the game that he felt good enough to stay on the mound. With his pitch count at 97, there was no use in risking his health.
"My foot went completely numb once it hit, but the more I moved it around the more I kind of flexed it around, the feeling came back and I was able to put all my pressure on it out there on the field," said Wacha, who is day to day. "I wanted to stay in there and keep pitching. My foot felt good enough to do it, but I guess it was time to come out."
Pitching in the ninth, Rosenthal suffered hamstring spasms on a 1-0 pitch to Ramon Flores with the potential winnning run on second and one out. He was lifted after Matheny and the trainers came out to check on him. Seung Hwan Oh replaced Rosenthal and gave up the game-winning single to Villar. Rosenthal is also day to day.
It was the continuation of a bad string of luck for the Cardinals, who have placed four players on the disabled list since June 30. Most recently -- and notably -- All-Star infielder Matt Carpenter suffered a right oblique strain while taking a swing Wednesday.
"It's something that every team goes through," Wacha said. "It's all about how you react to those situations, how you overcome them. I'm going to tell you, we're not going to make any excuses like that in this clubhouse. I think we have the guys that can step up and fill those positions. But obviously, you hate seeing guys get knocked out of the game and coming out due to injury."
Curt Hogg is a reporter for MLB.com based in Milwaukee. This story was not subject to the approval of Major League Baseball or its clubs.