Helton's two-bagger drove in two runs during the key three-run fourth inning of the Rockies' 6-4 victory over the D-backs at Chase Field.
To catch Gehrig was special for Helton.
"It's an honor to be mentioned at any level with a guy like that," Helton said. "That's a lot of doubles. I always considered myself a gap-to-gap hitter, and that's the way you get doubles.
"More important, there were two guys on, and they turned out to be pretty big runs."
Next on the list is another Hall of Famer, Al Simmons, who doubled 539 times from 1924 to 1944. The all-time leader is Hall of Famer Tris Speaker, with 792.
Thomas Harding is a reporter for MLB.com. Read his blog, Hardball in the Rockies, and follow him on Twitter @harding_at_mlb. This story was not subject to the approval of Major League Baseball or its clubs.