After Jason Lane reached on an error with two outs, the right-hander bent over on the mound and was checked out by assistant trainer Jim Lovell.
Manager Bobby Cox talked to Cormier before signaling to the bullpen.
Cormier was tied for the lead in the Grapefruit League with three victories and went into the game with a 1.29 ERA. The first five Astros were retired harmlessly before shortstop Chris Woodward booted Lane's grounder. Cormier threw 19 pitches, 11 for strikes.
Guy Curtright is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.