The players listed below could provide difference-making stats for DraftKings participants on Friday.
Starlin Castro: The second baseman could provide production at a premium position when he brings his lifetime .761 OPS against left-handers (.712 vs. righties) into a matchup at his hitter-friendly home park against southpaw Tommy Milone (career 4.04 ERA, 1.30 WHIP). Castro could also thrive against a Twins bullpen that ranks 27th in the Majors with a 4.61 ERA.
Carlos Beltran: The switch-hitting outfielder -- who has hit 19 homers across 248 at-bats this season -- owns balanced career splits that include a .282/.345/.510 slash line against left-handers. Beltran could go deep or drive in multiple runs when he bats at his offense-inducing home park against the southpaw Milone (5.79 ERA, 1.41 WHIP in 2016) and an unreliable Twins bullpen.
Joey Votto: The first baseman has used a patient, powerful approach to build an impressive lifetime .314/.432/.543 slash line against right-handers. Votto could go deep or drive in multiple runs when he bats at his hitter-friendly home park against righty Colin Rea (career 4.79 ERA, 1.36 WHIP) and a Padres bullpen that ranks 24th in baseball with a 4.38 ERA.
Jay Bruce: The outfielder has long fared best vs. right-handers, against whom he has logged a lifetime .817 OPS (.726 vs. lefties). Bruce could have success when he bats at his offense-inducing home park against the right-handed Rea (5.02 ERA, 1.41 WHIP in 2016) and a Padres squad that ranks 29th in the Majors with a .676 defensive efficiency ratio.
Josh Donaldson: Since joining the Blue Jays at the outset of 2015, the third baseman has produced an impressive .306/.412/.601 slash line against left-handers. Donaldson could post a notable DraftKings total when he hits at offense-inducing U.S. Cellular Field against southpaw Carlos Rodon (4.16 ERA, 1.49 WHIP in 2016).
Troy Tulowitzki: Hitting .215 this season, the shortstop could have a reduced price tag in DraftKings contests when he brings his lofty lifetime .941 OPS against left-handers (.846 vs. righties) into a matchup with the southpaw Rodon (career 1.46 WHIP) at Chicago's hitter-friendly venue.
Denard Span: Hitting leadoff, the outfielder could reach base often and score multiple runs when he brings his lifetime .758 OPS against right-handers (.709 vs. lefties) into a matchup with rookie righty Zach Eflin (10.80 ERA, 2.04 WHIP) and a Phillies bullpen that ranks 25th in baseball with a 4.42 ERA.
Paul Goldschmidt: With a lifetime .336/.437/.602 slash line against left-handers, the first baseman has proven to wield a potent bat during those matchups. Goldschmidt could post a game-changing DraftKings total when he faces rookie southpaw Tyler Anderson (two starts) at homer-happy Coors Field.
Welington Castillo: With a lifetime .873 OPS against left-handers that exceeds his .682 mark vs. righties, Castillo could provide production at a premium position when he bats at Colorado's hitter-friendly park against the inexperienced lefty Anderson and a Rockies relief corps that ranks 26th in baseball with a 4.56 ERA.
Curtis Granderson: Hitting leadoff, Granderson may maximize his opportunities to reach base and score runs when he takes his lifetime .859 OPS against right-handers (.692 vs. lefties) into a matchup with Braves rookie righty Aaron Blair (7.19 ERA, 1.71 WHIP). The outfielder could also swipe a base against either A.J. Pierzynski or Tyler Flowers, who have combined to throw out just nine of 61 would-be base stealers in 2016.
Michael Conforto: The second-year outfielder owns some of the most lopsided splits in baseball, with an .872 OPS against right-handers in comparison to a .282 mark vs. lefties. Hitting .153 since the outset of May, Conforto could have a reduced cost in DraftKings contests when he faces the inexperienced righty Blair (46 1/3 innings) and a Braves bullpen that ranks 22nd in the Majors with a 4.33 ERA.
Neil Walker: Having compiled 14 homers across 230 at-bats, the second baseman has been one of the most powerful players at his premium position this season. Walker could go deep or drive in multiple runs when he brings his lifetime .794 OPS against right-handers (.683 vs. lefties) into a matchup with the rookie righty Blair (5.82 FIP) and a shaky Braves relief corps.
Masahiro Tanaka: With a 3.10 ERA and a 1.02 WHIP in the Majors, the right-hander has the skills to thrive when he faces Milone (5.79 ERA, 1.41 WHIP in '16) and a Twins lineup that ranks 21st with a .709 OPS against righties
Jake Peavy: With a 5.47 ERA and a 1.44 WHIP this season, the right-hander could have a reduced cost in DraftKings contests when he works at his pitcher-friendly home park against a Phillies lineup that ranks 28th in the Majors with a .658 OPS against righties.
Max Scherzer: Having posted a 2.99 ERA, a 1.01 WHIP and a 10.6 K/9 rate since the outset of 2013, the right-hander ranks among the most dominant starters in baseball. Scherzer could post a notable DraftKings total when he tangles with a Brewers lineup that ranks second in the Majors with 684 strikeouts.
Steven Matz: With a 2.58 ERA and a 1.17 WHIP across 18 career starts, the left-hander has already become a trusted option for DraftKings participants. Matz could deliver a stellar performance when he faces a Braves lineup that ranks last in the Majors in OPS vs. southpaws (.583) and total home runs (33).
All statistics are accurate through the completion of Wednesday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.