Mets manager Terry Collins confirmed that Syndergaard could be used in the late innings of what ultimately was a 6-4 loss to the White Sox on Tuesday night, and in the seventh inning Syndergaard emerged from the bullpen for his first career regular-season relief appearance.
As he trotted to the mound, the 23-year-old received a thunderous standing ovation from the crowd of 32,781 on hand as his warmup music "Carmina Burana" blared from the Citi Field speakers.
While toeing the rubber, Syndergaard did not disappoint -- tossing a scoreless frame, allowing only one runner to reach on an error, while striking out two.
"I wanted to be up 8-0 and to have him pitch in the ninth, but I didn't get that," Collins said. "In a one-run game, I had my choice with the top of the order coming up to either put [Hansel] Robles in and leave the bottom of the order for Noah in the eighth, but I thought getting the top half was most important, so I brought him in."
Robles entered in the eighth and allowed three runs, including Tyler Saladino's go-ahead two-run homer.
Syndergaard began his outing by striking out Adam Eaton on five pitches: a 100-mph fastball, two straight 101-mph fastballs, a 94-mph slider and finally a 101-mph fastball.
Brett Lawrie reached on an error by Asdrubal Cabrera on the ensuing at-bat and stole second after Syndergaard got Jose Abreu to fly out to center.
With a runner in scoring position and Todd Frazier, who had drilled a two-run homer the inning before, at the plate, Syndergaard ran the count full before getting the Chicago third baseman to swing over the top of a 92-mph changeup on the seventh pitch of the at-bat.
"He looked great out of the bullpen," catcher Kevin Plawecki said. "He made a big pitch to Frazier there with the changeup and got out of a jam there. He came out throwing gas and looked really good."
Nine of Syndergaard's 17 pitches clocked in at 100-plus mph, and 14 of them were for strikes.
Syndergaard's only other career relief appearance came in the seventh inning of Game 5 in last year's National League Division Series, when he also fired a scoreless frame.