The Angels' designated hitter took a slider from Tigers reliever Mark Lowe and deposited it into the bullpen in left for a two-run, walk-off blast and an 11-9 Angels victory.
"It's a great walk-off win," Angels manager Mike Scioscia said. "The way we had things set up, I was hoping we'd be talking about a couple different things tonight."
It was Cron's second homer of the game, giving him his first career walk-off and fourth-career multi-homer performance.
"Just put a good swing on it," Cron said of the at-bat, after Albert Pujols led off the ninth with a walk. "Whatever happens, happens. [Pujols] had a great at-bat ahead of me, I thought my job was just to keep it rolling. I got a good pitch to hit, and I put a good swing on it."
Long before Cron's winning hit, the Angels looked to be firmly in control. They had scored in each of the first four innings, building a 9-2 lead for starter Hector Santiago. The left-hander had solid stuff Tuesday, often hitting 95 mph on his fastball, but he couldn't get out of trouble.
In the sixth, he left a hanging curveball over the plate for a two-run homer from Tigers right fielder J.D. Martinez. In the seventh, he walked the first two hitters before being taken out. Cam Bedrosian walked the next hitter before serving up a grand slam to second baseman Ian Kinsler.
"A couple pitches didn't go my way to put me behind in the count, and they laid off a couple really good pitches," Santiago said. "I get taken out and Cam had some good pitches. He left one over the plate, and they got us."
Cron's walk-off was the game's ninth home run, tied for the most in any game in the Majors this season with the Rockies-Reds' total from earlier Tuesday.
"Interesting is one way to put it," Scioscia said of the game.
Added Santiago: "It's baseball. They put a lot of good swings on balls to come back and tie it. We came out on top, and that's all you can ask for."
Angels closer Huston Street, who earned the win after throwing a perfect ninth, saw the slugfest win as something for the Angels to build on.
"When you win games like tonight, looking back over the season, you have to win a couple games like that," he said. "You run out to an early lead, you kind of squander it, but you figure out a way to get a win."
Fabian Ardaya is a reporter for MLB.com based in Anaheim. This story was not subject to the approval of Major League Baseball or its clubs.