The players listed below could provide difference-making stats for DraftKings participants on Wednesday.
Odubel Herrera: With a 31-to-31 walk-to-strikeout ratio, the outfielder has made notable improvements at the plate this season. Herrera could thrive when he brings his lifetime .825 OPS against right-handers (.719 vs. lefties) into a matchup with Tigers righty Anibal Sanchez (6.23 ERA, 1.59 WHIP in 2016).
Maikel Franco: From the heart of Philadelphia's lineup, Franco could drive in multiple runs when he brings his lifetime .791 OPS against right-handers (.696 vs. lefties) into a matchup with the righty Sanchez. The third baseman could also thrive late in the game against a Tigers bullpen that ranks 22nd in the Majors with a 4.02 ERA.
Gregory Polanco: The outfielder has produced pronounced lifetime splits, with a .771 OPS against right-handers that far exceeds his .546 mark vs. lefties. Polanco has the plate skills to thrive against D-backs righty Rubby De La Rosa (career 4.41 ERA, 1.37 WHIP) and a D-backs bullpen that ranks 23rd in the Majors with a 4.06 ERA.
John Jaso: From his perch atop the lineup, Jaso could reach base often or score multiple runs when he brings his lifetime .802 OPS against right-handers (.537 vs. lefties) into a matchup with the right-handed De La Rosa and an unreliable D-backs relief corps.
Brian McCann: With 32 homers since the outset of 2015, the left-handed-hitting catcher is among the most powerful players at his premium position. McCann could rip a round-tripper when he brings his lifetime .825 OPS against right-handers (.750 vs. lefties) into a matchup against Blue Jays fly-ball-prone righty Marco Estrada (career 1.3 HR/9 rate) at Yankee Stadium, which is especially homer happy for lefty batters.
David Ortiz: During his accomplished career, Ortiz has recorded a lofty lifetime .294/.397/.582 slash line against right-handers. Hitting .329 with 11 homers across 152 at-bats this season, Ortiz will be ready to post a game-changing total in DraftKings contests when he faces Rockies righty Chad Bettis (career 4.98 ERA, 1.49 WHIP).
Travis Shaw: The third baseman will be in prime position to improve on his lifetime .285/.359/.489 slash line against right-handers when he tangles with the righty Bettis (4.18 ERA in 2016). Shaw could also thrive late in the game against a Rockies relief corps that ranks 24th in baseball with a 4.16 ERA.
Paul Goldschmidt: With a lifetime .325/.427/.593 slash line against left-handers, Goldschmidt has proven to wield a potent bat during those matchups. The first baseman has the plate skills to thrive against Pirates lefty Jeff Locke (career 4.23 ERA, 1.40 WHIP) and the speed (26 steals since the outset of 2015) to swipe a base against Francisco Cervelli, who has allowed more stolen bases than any other catcher since the start of 2015.
Welington Castillo: Hitting .288 with seven homers across 132 at-bats, the catcher has been among the most productive players at his premium position this season. Castillo could go deep or drive in multiple runs when he takes his lifetime .875 OPS against left-handers (.693 vs. righties) into a matchup with the left-handed Locke (5.00 ERA, 1.58 WHIP in 2016).
Yasmany Tomas: With a lifetime .889 OPS against left-handers that exceeds his .675 mark vs. righties, the second-year outfielder could thrive against the lefty Locke and a Pirates bullpen that ranks 26th in baseball with a 4.24 ERA.
Mike Trout: With a lifetime .312/.398/.573 slash line against right-handers, the outfielder has proven to be among the best in baseball during those matchups. Trout could be worth a major investment in DraftKings contests when he bats at hitter-friendly Globe Life Park in Arlington against righty Colby Lewis (career 4.70 ERA, 1.35 WHIP).
Chris Davis: Since the outset of 2013, the first baseman has used a patient, powerful approach to log a .261/.372/.584 slash line against right-handers. Davis could go deep or drive in multiple runs when he tangles with Astros righty Collin McHugh (5.13 ERA, 1.58 WHIP in 2016).
Jonathan Schoop: Having ripped 23 round-trippers across 453 at-bats since the outset of 2015, the second baseman has proven to be among the most powerful players at his premium position. Schoop could put a ball into the outfield seats or drive in multiple runs when he faces the righty McHugh (career 4.15 ERA). Also working in Schoop's favor: Houston ranks 29th in baseball with a .671 defensive efficiency ratio.
Leonys Martin: With eight homers and seven steals across 160 plate appearances, the outfielder has made a major impact in many 2016 DraftKings contests. Martin could contribute in multiple ways when he brings his lifetime .717 OPS against right-handers (.583 vs. lefties) into a matchup with A's righty Zach Neal, who will be making his first career start.
Junior Guerra: Having produced a 3.96 ERA and a 1.04 WHIP, the rookie right-hander has emerged as a viable second-starter option for DraftKings participants. Guerra could excel in a matchup at pitcher-friendly Turner Field against a Braves lineup that ranks 29th in the Majors in OPS vs. right-handers (.645) and last in baseball in total home runs (18).
Jake Arrieta: Sitting at 8-0 with a 1.29 ERA and a 0.84 WHIP, the right-hander has been one of the most effective starters in the Senior Circuit this season. Arrieta could post an impressive total in DraftKings contests when he brings his 2.14 ERA and 0.93 WHIP as a member of the Cubs into a matchup with the Cardinals.
Hisashi Iwakuma: Having produced a 4.39 ERA and a 1.41 WHIP this season, the right-hander could have a reduced cost in DraftKings contests when he brings his lifetime 3.26 ERA and 1.11 WHIP into a matchup at his pitcher-friendly home park against the A's. Working in Iwakuma's favor: the A's lineup ranks 26th in the Majors with a .679 OPS against righties and is missing injured left-handed-hitting slugger Josh Reddick.
All statistics are accurate through the completion of Monday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB. This story was not subject to the approval of Major League Baseball or its clubs.