Robinson Cano: Much of the second baseman's impressive career resume can be traced to his lifetime .317/.365/.526 slash line against right-handers. Cano could hit his 13th homer of the season or drive in multiple runs when he vacates his pitcher-friendly home venue and faces Reds righty Alfredo Simon (10.34 ERA, 2.11 WHIP in 2016) at hitter-friendly Great American Ball Park.
Kyle Seager: In his six-year career, the third baseman has posted an .803 OPS against right-handers that exceeds his .703 mark vs. lefties. Seager could display his power when he faces the righty Simon (7.08 FIP in 2016) and a Reds relief corps that sits last in the Majors with a 6.76 ERA.
Leonys Martin: With seven homers and seven steals across 147 plate appearances, the outfielder has been an impactful player in many 2016 DraftKings contests. Martin could contribute in multiple ways when he brings his lifetime .714 OPS against right-handers (.565 vs. lefties) into a matchup with the righty Simon and an unreliable Reds relief corps.
Gregory Polanco: The outfielder has produced notable career splits, with a .772 OPS against right-handers that exceeds his .550 mark vs. lefties. Polanco has the plate skills to thrive in a matchup against Rockies righty Chad Bettis (career 4.98 ERA, 1.49 WHIP).
John Jaso: Hitting leadoff, the first baseman -- who owns a lifetime .362 on-base percentage -- may maximize his opportunities to reach base and score runs at the expense of the righty Bettis (4.18 ERA in 2016) and a Rockies bullpen that ranks 26th in the Majors with a 4.41 ERA.
Michael Saunders: With a lifetime .718 OPS against right-handers (.664 vs. lefties), the outfielder could thrive in a matchup with righty Phil Hughes (career 4.38 ERA, 1.28 WHIP, 1.2 HR/9 rate) and a Twins bullpen that ranks 28th in the Majors with a 4.89 ERA. Also working in Saunders' favor: Minnesota ranks last in the Majors with a .689 defensive efficiency ratio.
Chris Davis: Since the outset of 2013, the first baseman has used a patient, powerful approach to post a .262/.374/.587 slash line against right-handers. Davis is a prime candidate to rip a round-tripper when he faces Angels fly-ball-prone righty Jered Weaver (5.76 ERA, 1.61 WHIP in 2016).
Jonathan Schoop: With 22 homers across 447 at-bats since the outset of 2015, the second baseman is among the most powerful players at his premium position. Schoop could put a ball into the outfield seats when he faces Weaver, who has produced a 4.89 ERA, a 1.32 WHIP and a 1.5 HR/9 rate since the outset of 2015.
Michael Conforto: Since debuting on July 24, 2015, the outfielder has registered notable splits that include a .935 OPS against right-handers in comparison to a .371 mark vs. lefties. Conforto could post an impactful total in DraftKings contests when he faces right-hander Chase Anderson (5.32 ERA, 1.41 WHIP in 2016) and a Brewers bullpen that ranks 19th in the Majors with a 3.97 ERA.
Curtis Granderson: Hitting .195 this season, the outfielder could have a reduced cost in DraftKings contests when he takes his lifetime .856 OPS against right-handers (.694 vs. lefties) into a matchup with the righty Anderson and a suspect Brewers relief corps. Granderson could also swipe a base against Jonathan Lucroy, who has allowed more steals than any other catcher in 2016.
Yasmani Grandal: With balanced career splits, the catcher could provide production at a premium position when he tangles with right-hander Colin Rea (career 4.32 ERA, 1.35 WHIP) and a Padres relief corps that ranks 24th in the Majors with a 4.24 ERA.
Kenta Maeda: After posting a 2.39 ERA and a 1.09 WHIP across eight seasons in the Japan Central League, the right-hander has registered a 2.87 ERA and a 1.09 WHIP across his initial eight Major League starts. Maeda could spin a gem when he works at pitcher-friendly Petco Park against a Padres lineup that ranks last in the Majors with a .626 OPS against righties.
Jesse Hahn: The right-hander will be in position to have a stellar start when he brings his solid career 3.24 ERA into a matchup at his pitcher-friendly home park against a Yankees lineup that ranks 19th in the Majors with a .709 OPS against righties. Hahn could come away with a win if his supporting cast can extend the recent struggles of righty Michael Pineda (6.60 ERA in 2016).
Noah Syndergaard: With a 2.19 ERA, a 0.99 WHIP and an 11.0 K/9 rate this season, Syndergaard could post a game-changing total in DratKings contests when he works at home in a seemingly advantageous matchup with the Brewers' Anderson.
Jerad Eickhoff: Since debuting on Aug. 21, 2015, the right-hander has posted a solid 3.50 ERA and a 1.14 WHIP. Eickhoff could spin a gem when he faces a Braves lineup that ranks 29th in the Majors with a .651 OPS against righties and last in baseball with 18 home runs. Also of note: Atlanta ranks last in the National League with a 11-30 record.
All statistics are accurate through the completion of Friday's games.