The players listed below could provide difference-making stats for DraftKings participants on Sunday.
Zack Cozart: Hitting out of the leadoff spot, Cozart could maximize his chances to reach base and score runs when he brings his lifetime .728 OPS against left-handers (.650 vs. righties) into a matchup with Phillies southpaw Adam Morgan (career 4.40 ERA). The shortstop could also thrive against a Phils bullpen that is ranked 20th in baseball with a 4.03 ERA.
Brandon Phillips: Phillips has long fared best vs. left-handers, against whom he has posted a lifetime .797 OPS (.722 vs. righties). The second baseman could thrive against Morgan, who in his career has allowed right-handed hitters such as Phillips to post a .785 OPS (.659 OPS allowed to lefty batters).
Lucas Duda: The first baseman will be poised to display his power when he brings his lifetime .843 OPS against right-handers (.656 vs. lefties) into a matchup with Rockies righty Tyler Chatwood (career 4.20 ERA, 1.51 WHIP) at homer-happy Coors Field. Duda could also excel late in the game against a relief corps that is 27th in baseball with a 4.73 ERA.
Curtis Granderson: The Mets' leadoff hitter may maximize his opportunities to reach base and score runs at the expense of Chatwood (career 4.48 FIP) and an unreliable Rockies bullpen. As a big leaguer, Granderson has posted a .857 OPS against right-handers that exceeds his .696 mark vs. lefties.
Neil Walker: In his career, the second baseman has produced a .798 OPS against right-handers that exceeds his .670 mark vs. lefties. Walker -- who has hit nine homers over 121 at-bats this season -- could go deep when he tangles with Chatwood and a shaky relief corps at Colorado's hitter-friendly park.
Michael Conforto: Since debuting on July 24, 2015, Conforto has produced a .925 OPS against right-handers in comparison to a .409 mark vs. lefties. The outfielder could be part of a Mets stack -- including Duda, Granderson and Walker -- against Chatwood.
Brandon Belt: Among his 67 career homers, Belt has gone deep 49 times against right-handers and 46 times on the road. The first baseman could rip a round-tripper when he vacates his pitcher-friendly home park and faces righty Rubby De La Rosa (career 1.3 HR/9 rate) at offense-inducing Chase Field.
Denard Span: From his perch atop the lineup, Span could reach base often and score multiple runs when he tangles with De La Rosa (career 4.46 ERA, 1.38 WHIP) and a D-backs relief corps that ranks 18th in baseball with a 3.90 ERA. In his career, Span has registered a .762 OPS against righties that exceeds his .705 mark vs. southpaws.
Brandon Crawford: With balanced career splits, the shortstop could excel against De La Rosa in Arizona. In his career, De La Rosa has allowed left-handed batters such as Crawford to post an .855 OPS (.686 OPS allowed to righty batters).
Brian McCann: Among the most powerful players at his premium position, the left-handed-hitting catcher could go deep when he brings his lifetime .824 OPS against right-handers (.753 vs. lefties) into a home matchup against White Sox righty Miguel Gonzalez (career 4.70 FIP, 1.3 HR/9 rate). Working in McCann's favor: Yankee Stadium is especially power-inducing for lefty batters.
Chris Davis: Since the outset of 2013, the first baseman has used a patient, powerful approach to build a .264/.374/.593 slash line against right-handers. Davis could rip a round-tripper when he bats at his hitter-friendly home park against Tigers righty Michael Fulmer, who has produced a 6.00 ERA and a 2.00 WHIP over his initial three big league starts.
Pedro Alvarez: Hitting .214 with two homers in 72 at-bats this season, the left-handed slugger could have a reduced cost in DraftKings contests when he brings his lifetime .793 OPS against right-handers (.594 vs. lefties) into a matchup with the inexperienced Fulmer.
Jean Segura: Hitting .351 with five homers and five steals over 160 plate appearances, the shortstop has been among the most productive players at his premium position this season. Hitting leadoff, Segura could maximize his chances to produce at the expense of Giants righty Matt Cain (6.69 ERA, 1.51 WHIP in 2016).
Jake Lamb: The third-year third baseman has logged a lifetime .762 OPS against right-handers in comparison to a .533 mark vs. lefties. Lamb could drive in multiple runs when he tangles with Cain (6.14 ERA, 1.51 WHIP since the beginning of 2015). Also of note: Lamb will put balls into play against a Giants defense that ranks last in the Majors with a .677 defensive efficiency ratio.
Dan Straily: Having posted a 3.47 ERA and a 1.13 WHIP this season, the right-hander has pitched well enough to receive second-starter consideration by DraftKings participants for his matchup against a Phillies lineup that ranks 28th in the Majors with a .651 OPS against righties.
Felix Hernandez: With a lifetime 3.10 ERA and a 1.17 WHIP, the right-hander has the skills to spin a gem when he works at his pitcher-friendly home park against an Angels lineup that ranks 26th in the Majors with a .675 OPS against righties.
Matt Moore: With a 4.83 ERA and a 1.34 WHIP this season, the left-hander could be a cost-effective second starter in DraftKings contests when he works against an A's lineup that ranks 25th in the Majors with a .647 OPS against southpaws. Also working in Moore's favor: Tampa Bay ranks fifth in baseball with a .726 defensive efficiency ratio.
All statistics are accurate through the completion of Friday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB. This story was not subject to the approval of Major League Baseball or its clubs.