Bryce Harper: With a .319/.457/.641 slash line since the outset of 2015, the outfielder is arguably the most effective offensive player in baseball. Harper could post a game-changing total when he brings his lifetime .959 OPS against right-handers (.797 vs. lefties) into a matchup with Marlins righty Tom Koehler (career 4.19 ERA, 1.35 WHIP).
Daniel Murphy: Hitting .409, the second baseman has been one of the hottest hitters in baseball this season. Recently inserted into the cleanup spot behind Harper, Murphy could drive in multiple runs when he brings his lifetime .795 OPS against right-handers (.688 vs. lefties) into a matchup with the right-handed Koehler (5.83 ERA, 1.60 WHIP in 2016).
Joey Votto: The first baseman has combined elite power and patience to produce an impressive lifetime .315/.432/.544 slash line against right-handers. Votto could go deep or drive in multiple runs when he bats at hitter-friendly Citizens Bank Park against righty Jeremy Hellickson, who has logged a 4.86 ERA and a 1.36 WHIP since the outset of 2013.
Jay Bruce: The outfielder has long fared best vs. right-handers, against whom he owns a lifetime .810 OPS (.713 vs. lefties). Bruce -- who has collected six homers and 23 RBIs across 111 at-bats this season -- could display power when he tangles with the righty Hellickson (4.91 ERA, 1.39 WHIP in 2016) and a Phillies bullpen that ranks 21st in baseball with a 4.17 ERA.
Lucas Duda: As a big leaguer, Duda has registered an .843 OPS against right-handers that exceeds his .657 mark vs. lefties. The first baseman could go deep when he bats at homer-happy Coors Field against righty Jon Gray (career 5.49 ERA, 1.49 WHIP) and a Rockies relief corps that ranks 28th in the Majors with a 4.81 ERA.
Michael Conforto: The second-year outfielder has registered notable career splits, with a .923 OPS against right-handers that exceeds his .409 mark vs. lefties. Expected to bat out of a premium lineup spot, Conforto could post a notable total in DraftKings contests when he faces the right-handed Gray (5.40 ERA in 2016) and a suspect bullpen at Colorado's offense-inducing venue.
Curtis Granderson: Hitting leadoff, Granderson could maximize his chances to reach base and score runs when he brings his lifetime .857 OPS against right-handers (.696 vs. lefties) into a matchup with the righty Gray and an unreliable Rockies relief corps. With a .205 batting average this season, the outfielder may have a reduced cost in DraftKings contests.
Matt Duffy: The third baseman will be in position to excel when he vacates his pitcher-friendly home park and brings his lifetime .763 OPS against right-handers (.676 vs. lefties) into a matchup with righty Shelby Miller (7.36 ERA, 1.77 WHIP in 2016) at offense-inducing Chase Field.
Brandon Crawford: With balanced career splits, the shortstop could thrive at Arizona's hitter-friendly venue against Miller and a D-backs relief corps that ranks 20th in the Majors with a 4.09 ERA. In his career, Miller has allowed left-handed batters such as Crawford to post a .737 OPS (.633 OPS allowed to righty batters).
Mitch Moreland: The first baseman could rip a round-tripper when he brings his lifetime .797 OPS against right-handers (.648 vs. lefties) into a matchup at his hitter-friendly home park against Blue Jays righty R.A. Dickey (career 4.00 ERA, 1.1 HR/9 rate).
Adam Eaton: Hitting leadoff, Eaton could have ample opportunity to excel when he brings his lifetime .780 OPS against right-handers (.722 vs. lefties) into a matchup with righty Luis Severino (6.12 ERA, 1.48 WHIP in 2016) at hitter-friendly Yankee Stadium. The outfielder could also swipe a base against catcher Brian McCann, who has thrown out just three of 17 would-be base stealers this year.
Jason Kipnis: The second baseman could reach base often and score multiple runs when he brings his lifetime .811 OPS against right-handers (.655 vs. lefties) into a matchup with righty Ricky Nolasco, who has a 5.48 ERA and a 1.49 WHIP since joining the Twins at the outset of 2014. Kipnis could also swipe a base against catcher Kurt Suzuki, who sometimes struggles to thwart would-be base stealers.
Chris Sale: With a 2.85 ERA, a 1.06 WHIP and a 10.2 K/9 rate in his career, the left-hander is arguably the most dominant starter in the American League. Sale could post a game-changing total in DraftKings contests when he faces a Yankees lineup that ranks 23rd in the Majors with a .685 OPS against southpaws.
Nathan Karns: Karns could fare well at his pitcher-friendly home park when he faces an Angels lineup that ranks 28th in the Majors with a .640 OPS against righties. After a slow start with Seattle, the righty has allowed four runs across his past 19 1/3 innings.
Jake Odorizzi: The right-hander -- who has a 3.10 ERA and a 1.16 WHIP this season -- could dominate when he works at his offense-suppressing home park against an A's lineup that ranks 23rd in baseball with a .687 OPS against righties. Also of note: Odorizzi will have the benefit of working in front of a Rays squad that ranks second in the Majors with a .718 defensive efficiency ratio.
Steven Wright: In his career, Wright has logged a 2.98 ERA when working as a starter. The Boston knuckleballer (1.52 ERA in 2016) could compile six-plus effective innings and a handful of strikeouts when he faces an Astros lineup that leads the Majors with 345 whiffs.