The players listed below could provide difference-making stats for DraftKings participants on Wednesday.
Nolan Arenado: In his career, Arenado has fared best when facing left-handers (.291/.355/.534 slash line) and batting at his hitter-friendly home park (.309/.349/.569 slash line). The third baseman may be worth a major expenditure in DraftKings contests when he competes at Coors Field against D-backs southpaw Robbie Ray (career 4.43 ERA, 1.47 WHIP).
Ryan Raburn: The outfielder has thrived vs. lefties since the outset of '15, hitting 1.055 OPS in matchups against them. At his hitter-friendly home venue on Wednesday, he could thrive in a matchup against the southpaw Ray, who in his career has allowed right-handed hitters such as Raburn to produce an .817 OPS (.702 OPS allowed to lefty batters).
Odubel Herrera: Herrera could improve upon his lifetime .799 OPS against right-handers (.745 vs. lefties) when he faces righty Jhoulys Chacin (5.40 ERA, 1.39 WHIP in 2016) and a Braves bullpen that ranks 26th in the Majors with a 4.73 ERA. As a big leaguer, Chacin has allowed left-handed batters such as Herrera to post a .765 OPS (.663 OPS allowed to righty batters).
David Peralta: The outfielder has produced pronounced career splits, with an .888 OPS against right-handers that exceeds his .613 mark vs. lefties. Peralta could have a great game when he bats at homer-happy Coors Field against righty Chad Bettis (career 5.07 ERA, 1.50 WHIP) and a Rockies relief corps that ranks 27th in the Majors with a 4.75 ERA.
Jake Lamb: The third-year third baseman has logged a lifetime .769 OPS against right-handers in comparison to his .560 mark vs. lefties. Lamb could drive in multiple runs when he tangles with the right-handed Bettis (4.40 ERA in 2016) and an unreliable Rockies bullpen.
John Jaso: The first baseman has long fared best vs. right-handers, against whom he has a lifetime .798 OPS (.547 vs. lefties). Jaso could reach base often and score multiple runs when he bats at hitter-friendly Great American Ball Park against righty Alfredo Simon (career 4.33 ERA, 1.36 WHIP) and a Reds relief corps that ranks last in the Majors with a 6.43 ERA.
Gregory Polanco: The outfielder has produced notable career splits, with a .764 OPS against right-handers that exceeds his .524 mark vs. lefties. Polanco could reach base often and score multiple runs when he faces the right-handed Simon (9.86 ERA, 2.19 WHIP in 2016) and an unreliable Reds relief corps.
Nomar Mazara: Since making his big league debut on April 10, the outfielder has posted an impressive .309/.372/.515 slash line against right-handers. From the No. 2 spot in the Rangers' lineup, Mazara could have an outstanding game when he tangles with White Sox righty Mat Latos (4.42 ERA, 1.28 WHIP since the outset of 2015).
Derek Dietrich: Set to serve as Miami's starting second baseman for the foreseeable future, Dietrich will bring a lifetime .792 OPS against right-handers (.637 vs. lefties) into a matchup with Brewers righty Chase Anderson (6.44 ERA, 1.84 WHIP in 2016). The slugger -- who has compiled 26 homers across 686 career at-bats -- could also excel against a Brewers bullpen that ranks 25th in the Majors with a 4.57 ERA.
Christian Yelich: Hitting .333 this season, the outfielder will bring a hot bat and a lifetime .817 OPS against right-handers (.704 vs. lefties) into a matchup with the right-handed Anderson (career 4.40 ERA, 1.38 WHIP). Also of note: Milwaukee ranks last in baseball with a .660 defensive efficiency ratio, a fact that increases Yelich's chances of tallying hits.
Eric Hosmer: Since the outset of 2015, the lefty-hitting Hosmer has produced an impactful .322/.391/.510 slash line against right-handers. The first baseman could put a ball into the outfield seats when he faces righty Michael Pineda (career 1.1 HR/9 rate) at Yankee Stadium, which is especially homer-happy for left-handed batters.
Ryan Braun: With a lifetime .335/.403/.629 slash line against left-handers, Braun has proven to be among the best in baseball during those matchups. The outfielder -- who is hitting .363 with seven homers across 113 at-bats this season -- could go deep when he faces Marlins southpaw Wei-Yin Chen (career 1.2 HR/9 rate).
Jerad Eickhoff: The right-hander has been impressive since making his debut last August, posting a 3.30 ERA, a 1.09 WHIP and an 8.6 K/9 rate. Eickhoff could spin a gem when he works at pitcher-friendly Turner Field against a Braves lineup that ranks last in the Majors in both OPS against righties (.610) and total home runs (seven).
Rick Porcello: With a 2.95 ERA and a 0.96 WHIP, Porcello has been among the most effective starters in the American League this season. The right-hander could compile six-plus quality frames and a handful of whiffs when he faces an A's lineup that ranks 23rd in baseball with a .685 OPS against righties.
Taijuan Walker: The right-hander has taken a step forward this season, with a 1.97 ERA, a 1.03 WHIP and a 29-to-3 strikeout-to-walk ratio across 32 innings. Walker could post a notable total in DraftKings contests when he works at his pitcher-friendly home park against a Rays lineup that ranks 25th in the Majors with a .667 OPS against righties.
John Lackey: Having logged a 2.96 ERA since the outset of 2015, the right-hander could compile a handful of effective innings and a win when he leads a talented Cubs squad with an .800 winning percentage into a night home matchup against the Padres. San Diego's offense ranks 29th in the Majors with a .637 OPS against righties and has the third-most strikeouts in baseball (305).
Danny Salazar: With a 3.49 ERA and 9.9 K/9 rate in his career, Salazar has the skills to post a game-changing total in DraftKings contests. The right-hander will be poised to post a large strikeout total on Wednesday, when he faces an Astros lineup that leads the Majors with 318 whiffs.
All statistics are accurate through the completion of Monday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.