The players listed below could provide difference-making stats for DraftKings participants on Saturday.
Stephen Vogt: The catcher will be poised to provide production at a premium position when he brings his lifetime .766 OPS against right-handers (.633 vs. lefties) into a matchup with Astros righty Chris Devenski, who will be making his first big league start. The 25-year-old Devenski owns a career 4.37 ERA and a 1.36 WHIP in the Minors.
Michael Conforto: Hitting .338 with a .429 on-base percentage across 77 plate appearances this season, Conforto has emerged as one of the best outfielders in the National League. The young slugger could produce a notable total in DraftKings contests when he brings his lifetime .293/.367/.567 slash line against right-handers vs. the Giants' Matt Cain (5.95 ERA, 1.54 WHIP since the outset of 2015).
Lucas Duda: Duda has traditionally excelled vs. right-handers, against whom he has logged a lifetime .838 OPS (.669 vs. lefties). From the heart of the Mets lineup, the first baseman could be part of a stack -- including Conforto, second baseman Neil Walker and outfielder Curtis Granderson -- against the righty Cain (6.43 ERA, 1.67 WHIP in 2016).
Paul Goldschmidt: With a lofty lifetime .327/.428/.599 slash line against left-handers, Goldschmidt has proven to wield a potent bat in those matchups. The first baseman could produce a game-changing total in DraftKings contests when he bats at his hitter-friendly home park against lefty Chris Rusin, who in his career has allowed right-handed hitters such as Goldschmidt to post an .861 OPS (.718 OPS allowed to lefty batters).
Welington Castillo: The catcher -- who has hit six homers across 69 at-bats this season -- could display his power when he takes his lifetime .860 OPS against left-handers (.699 vs. righties) into a matchup with the southpaw Rusin (career 5.05 ERA, 1.51 WHIP). Castillo could also succeed late in the game against a Rockies relief corps that ranks 28th in the Majors with a 5.57 ERA.
Nick Ahmed: Hitting .190 this year, along with a lifetime .218/.269/.344 slash line, the right-handed-hitting shortstop could be a cost-effective option at a premium position as part of a D-backs stack -- along with Goldschmidt, Castillo and outfielder Yasmany Tomas -- against the lefty Rusin (career 4.65 FIP). As a big leaguer, Ahmed has logged a .701 OPS against left-handers that exceeds his .576 mark vs. righties.
Gregory Polanco: With substantial lifetime splits -- such as a .765 OPS against right-handers that dwarfs his .528 mark vs. lefties -- the outfielder could reach base often or score multiple runs when he faces righty Alfredo Simon (career 4.33 ERA, 1.36 WHIP). Polanco could also thrive late in the game against a Reds relief corps that ranks last in the Majors with a 6.22 ERA.
John Jaso: Jaso has long fared best vs. right-handers, against whom he has logged a lifetime .799 OPS (.542 vs. lefties). The first baseman could drive in multiple runs when he faces the right-handed Simon (5.59 ERA, 1.51 WHIP since the outset of 2015) and an unreliable Reds bullpen.
Prince Fielder: Much of Fielder's notable big league success can be traced to an impressive lifetime .297/.407/.547 slash line against right-handers. Hitting .190 this season, the slugger could have a reduced price tag in DraftKings contests when he bats at his hitter-friendly home park against Angels fly-ball-prone righty Matt Shoemaker (career 1.3 HR/9 rate).
Nomar Mazara: A premium prospect, Mazara has posted a .345/.415/.491 slash line since making his big league debut on April 10. The left-handed-hitting outfielder could use his premium lineup spot to post a notable total in DraftKings contests when he bats at his offense-inducing home park against the righty Shoemaker (4.74 ERA, 1.7 HR/9 rate since the outset of 2015).
Ryan Braun: In his productive career, the outfielder has registered a lofty .335/.403/.627 slash line against left-handers. Set to bat at his power-happy home park, Braun could go deep against Marlins southpaw Wei-Yin Chen (career 1.2 HR/9 rate).
Justin Bour: With a lifetime .807 OPS against right-handers that greatly exceeds his .589 mark vs. lefties, the first baseman will be poised to display his power when he vacates his pitcher-friendly home venue and faces the righty Chase Anderson (career 1.2 HR/9 rate) at homer-happy Miller Park.
Christian Yelich: With a .371/.489/.514 slash line this season, Yelich has been a regular contributor to DraftKings squads. From the three-hole in a lineup that includes superstar cleanup hitter Giancarlo Stanton, the outfielder could thrive in a matchup with Anderson (career 4.25 FIP) and an unreliable Brewers bullpen.
Francisco Liriano: Having logged a 3.32 ERA and a 9.6 K/9 rate since joining the Pirates at the outset of 2013, Liriano has the skills to spin a gem when he works at his offense-suppressing home park against the Reds in a seemingly advantageous matchup with Simon.
Ross Stripling: Since making his big league debut on April 8, Stripling has logged a solid 3.22 ERA. On Friday, the righty could be a cost-effective DraftKings option against Colin Rea (career 4.58 ERA) and the Padres at pitcher-friendly Dodger Stadium.
Jesse Hahn: Set to make his first start of the season, the right-hander owns a solid lifetime 3.23 ERA and a 1.19 WHIP. Hahn could be a serviceable second starter in DraftKings contests when he works at his pitcher-friendly home park against an Astros lineup that leads in the Majors with 224 strikeouts.
All statistics are accurate through the completion of Thursday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.