The 6-foot-4 Nix, the third-round pick of the Padres last June, allowed two hits with four strikeouts in four innings to lower his ERA to 3.86.
The 6-foot-3 De Los Santos, who was acquired from Seattle last offseason in the trade that sent reliever Joaquin Benoit to the Mariners, allowed two hits and three walks with four strikeouts in five innings to even his record at 1-1 and lower his ERA to 2.70.
Left fielder Rod Boykin (.213), drew a walk, moved to second on a single by center fielder Michael Gettys, moved to third on a wild pitch and scored on a ground out by third baseman Carlos Belen for the game's lone run.
Around the farm
TRIPLE-A EL PASO (8-10): The Chihuahuas had Wednesday off.
DOUBLE-A SAN ANTONIO (8-11): FRISCO 6, Missions 5. Starting RHP Brandon Morrow (1-1, 7.84 ERA) allowed six runs on 12 hits and two walks with a strikeout in 5 1/3 innings in his second rehab start with the Missions. RHP Kyle Lloyd (3.97) struck out three in 1 2/3 perfect innings. RHP Adam Cimber pitched a perfect eighth. 3B Gabriel Quintana (.220) was 2-for-4 with three RBIs, including a two-run homer. SS Jose Rondon (.365) was 2-for-5 with a double and a run scored.
CLASS A ADVANCED LAKE ELSINORE (9-11): High Desert 10, STORM 2. Starting RHP Martires Arias (0-2, 4.60ERA) allowed six runs (two earned) on a hit, four walks, a hit batter and a wild pitch in two-thirds of a first inning that also included an error and a passed ball. LHP Taylor Seidenberger (5.11) allowed four runs on three hits and a walk with five strikeouts in 2 1/3 innings. LHP Brad Wieck (1.46) allowed five hits with four strikeouts in two scoreless innings. RHP Colby Blueberg (2.45) allowed two hits with five strikeouts in two scoreless innings. LF Edwin Moreno (.175) hit a two-run homer in four at-bats for Lake Elsinore's only runs.