The players listed below could provide difference-making stats for DraftKings participants on Saturday.
Adrian Gonzalez: From his cleanup spot, the first baseman could drive in multiple runs when he travels to hitter-friendly Coors Field to face right-hander Tyler Chatwood (career 4.26 ERA). Gonzalez has traditionally fared best vs. right-handers, against whom he has posted a lifetime .902 OPS (.773 vs. lefties).
Joc Pederson: The outfielder has logged notable career splits, with a .781 OPS against right-handers that exceeds his .649 mark vs. lefties. Pederson could rip a round-tripper when he travels to offense-inducing Coors Field to face Chatwood (career 1.53 WHIP) and a Rockies bullpen that ranks 29th in the Majors with a 6.26 ERA.
Justin Turner: The third baseman -- who has hit .309 since joining the Dodgers at the outset of 2014 -- could have a terrific game when he brings his lifetime .794 OPS against right-handers (.711 vs. lefties) into a matchup with the right-handed Chatwood (career 4.54 FIP) at Colorado's homer-happy venue.
Corey Seager: Since making his big league debut on Sept. 3, 2015, Seager has registered an impressive .302/.362/.481 slash line against right-handers. The shortstop could provide stellar production at a premium position when he faces Chatwood and a suspect Rockies relief corps.
Scooter Gennett: The second baseman has produced some of the most lopsided lifetime splits in baseball, with an .800 OPS against right-handers that exceeds his .353 mark vs. lefties. Gennett could reach base often or score multiple runs when he bats at his hitter-friendly home park against right-hander Charlie Morton (career 4.53 ERA, 1.44 WHIP) and a Phillies bullpen ranks 27th in the Majors with a 5.33 ERA.
Bryce Harper: With a .329/.455/.667 slash line since the outset of 2015, Harper is arguably the most dangerous hitter in baseball. The outfielder could produce a difference-making total in DraftKings contests when he faces Twins right-hander Phil Hughes (career 4.33 ERA, 1.28 WHIP, 1.2 HR/9 rate).
Addison Russell: Since making his Major League debut on April 21, 2015, Russell has logged a .736 OPS against right-handers that notably exceeds his .504 mark vs. lefties. The shortstop could have an outstanding game when he travels to hitter-friendly Great American Ball Park to face right-hander Dan Straily (career 4.56 ERA).
Anthony Rizzo: From the heart of a loaded Cubs lineup, Rizzo will be in excellent position to excel when he brings his lifetime .267/.363/.490 slash line against right-handers into a matchup at Cincy's offense-inducing venue with the righty Straily (career 1.30 WHIP). The first baseman could also thrive late in the game against a Reds relief corps that ranks last in the Majors with a 6.75 ERA.
Jason Heyward: Heyward has long fared best vs. righties (.833 lifetime OPS) such as Straily, the owner of a career 4.71 FIP and a .750 OPS allowed to left-handed hitters (.680 OPS allowed to righty batters). Given his .179 average to start the season, the outfielder may come with an affordable DraftKings price tag.
Miguel Montero: With a lifetime .792 OPS against right-handers that notably exceeds his .657 mark vs. lefties, Montero will be poised to provide production at a premium position when he bats at the Cincinnati's offense-inducing park against the right-handed Straily and a shaky Reds relief corps.
Jean Segura: From his perch atop the lineup, Segura could reach base often and score multiple runs when he brings his balanced lifetime splits into a matchup with right-hander Juan Nicasio (career 4.87 ERA, 1.47 WHIP). The speedy shortstop may also swipe a base against Francisco Cervelli, who allowed more steals than any other catcher in 2015.
David Peralta: As a big leaguer, Peralta has logged an .895 OPS against right-handers that greatly exceeds his .591 mark vs. lefties. The outfielder could thrive against Nicasio, who in his career has allowed left-handed hitters such as Peralta to post an .836 OPS (.758 OPS allowed to righty batters).
Jose Fernandez: With a lifetime 2.47 ERA, 1.02 WHIP and 10.7 K/9 rate, Fernandez is arguably the most talented hurler on the Saturday docket. The right-hander could post a game-changing total in DraftKings contests when he faces the Giants at pitcher-friendly AT&T Park.
Michael Wacha: The right-hander will be in position to spin a gem when he brings his lifetime 3.19 ERA into a matchup with the Padres at pitcher-friendly Petco Park on Friday. Of note: San Diego ranks 29th in the Majors with .557 OPS against righties.
John Lackey: The right-hander -- who owns a 2.84 ERA since the outset of 2015 -- could combine six-plus effective innings with a win when he leads a talented Cubs team into a seemingly advantageous matchup with the Reds' Straily. Also of note: Cincinnati ranks 26th in the Majors with a .645 OPS against right-handed pitching.
Steven Matz: With a 3.25 ERA and an 8.9 K/9 rate since making his big league debut on June 28, 2015, the left-hander could post a substantial total in DraftKings contests when he travels to pitcher-friendly Turner Field to face a Braves lineup that ranks last in the Majors with a .503 OPS against southpaws.
All statistics are accurate through the completion of Thursday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB. This story was not subject to the approval of Major League Baseball or its clubs.