MLB.com Columnist

Fred Zinkie

Cubs could be on prowl to open weekend

Four North Siders could join Miggy, Harvey as today's top stars

Cubs could be on prowl to open weekend

Welcome to DraftKings fantasy baseball, the Official Daily Fantasy Game of Major League Baseball.

The players listed below could provide difference-making stats for DraftKings participants today.

Adrian Gonzalez: Gonzalez has long fared best vs. right-handers, against whom he has posted a lifetime .901 OPS (.773 vs. lefties). From the heart of the lineup, the first baseman could drive in multiple runs when he travels to hitter-friendly Coors Field to face right-hander Jon Gray (career 5.53 ERA, 1.62 WHIP).

Joc Pederson: The outfielder has produced pronounced career splits, with a .781 OPS against right-handers that exceeds his .649 mark vs. lefties. Pederson could have an outstanding game when he travels to offense-inducing Coors Field to face the righty Gray and a Rockies bullpen that ranks last in baseball with a 6.26 ERA.

Pederson's two-run homer

Justin Turner: The third baseman -- who has hit .309 since joining the Dodgers at the outset of 2014 -- could excel when he brings his lifetime .796 OPS against right-handers (.711 vs. lefties) into a matchup with the right-handed Gray and a suspect Rockies relief corps at homer-happy Coors Field.

Corey Seager: Since making his big league debut on Sept. 3, 2015, Seager has registered an impressive .314/.375/.500 slash line against right-handers. The shortstop could provide stellar production at a premium position when he faces the right-handed Gray, who has yet to make a start this season due to an abdominal injury.

Ryan Howard: With a career .282/.372/.565 slash line against right-handers, the first baseman will be in position to put a ball into the outfield seats when he faces righty Zach Davies (lifetime 4.71 ERA, 1.43 WHIP) at hitter-friendly Miller Park. Also of note: The Brewers' home venue is especially homer-happy for left-handed hitters such as Howard.

Howard's solo shot ties DiMaggio

Maikel Franco: Having logged a lifetime .290/.330/.477 slash line against right-handers, Franco will be poised to rip a round-tripper when he faces Davies (career 36 1/3 innings) at Milwaukee's offense-inducing venue. The third baseman could also excel late in the game against an injury-affected Brewers bullpen that lacks elite options.

Colby Rasmus: With 28 homers since the outset of 2015, Rasmus has emerged as one of the most powerful outfielders in the American League. He could go deep or drive in multiple runs when he brings his lifetime .790 OPS against right-handers (.675 vs. lefties) into a matchup with Red Sox righty Steven Wright (career 4.28 FIP, 1.30 WHIP).

Miguel Cabrera: With a lifetime .322/.389/.561 slash line against right-handers, Cabrera has proven to be among the best in baseball during those matchups. The first baseman could hit a homer when he faces Indians fly-ball-prone righty Josh Tomlin (career 1.5 HR/9 rate).

Addison Russell: The second-year shortstop -- who is also eligible at second base in DraftKings contests -- has logged a lifetime .743 OPS against right-handers that notably exceeds his .512 mark vs. lefties. Russell could have a great game when he travels to hitter-friendly Great American Ball Park to face right-hander Jon Moscot (career 4.67 ERA, 1.33 WHIP).

Anthony Rizzo: Rizzo will be in prime position to excel when he brings his lifetime .267/.363/.488 slash line against right-handers into a matchup at Cincy's offense-inducing venue with the inexperienced Moscot (17 1/3 career innings). The first baseman could also thrive late in the game against a Reds relief corps that ranks 29th in baseball with a 6.04 ERA.

Rizzo's solo homer

Jason Heyward: The outfielder owns notable lifetime splits, with a .832 OPS against right-handers in comparison to a .656 mark vs. lefties. From the two-hole in the Cubs' talent-laden lineup, Heyward could reach base often or score multiple runs when he faces the righty Moscot (career 6.46 FIP) and a shaky Reds bullpen at their hitter-friendly venue.

Evan Longoria: The centerpiece of the Rays lineup, Longoria could post a notable total in DraftKings contests when he vacates his pitcher-friendly home park and travels to homer-happy Yankee Stadium to face southpaw CC Sabathia (4.75 ERA, 1.43 WHIP since the outset of 2015). In his career, Longoria has logged a .914 OPS against left-handers that exceeds his .800 mark vs. righties.

Logan Forsythe: Hitting out of the leadoff spot, the second baseman could reach base often or score multiple runs when he brings his lifetime .828 OPS against left-handers (.641 vs. righties) into a matchup with Sabathia (4.64 FIP in 2015) at hitter-friendly Yankee Stadium.

Brandon Guyer: The outfielder could provide cost-effective production in DraftKings contests when he takes his lifetime .811 OPS against left-handers (.654 vs. righties) into a matchup with Sabathia, who has posted a 4.82 ERA and a 1.40 WHIP since the outset of 2013.

Adam Wainwright: With a 8.27 ERA and a 1.40 WHIP, Wainwright could have an economical price tag in DraftKings contests for his start against the Padres at pitcher-friendly Petco Park. Of note: San Diego ranks 29th in the Majors with .575 OPS against righties.

Jon Lester: Having produced a 3.24 ERA, a 1.10 WHIP and a 9.0 K/9 rate since joining the Cubs at the outset of last season, Lester has proven to be one of the most effective starters in the National League. He could compile six-plus innings, a notable strikeout total and a win when he leads a talented Cubs team into a seemingly advantageous matchup with the Reds' Moscot.

Lester fans 10 Rockies batters

Matt Harvey: With a 5.71 ERA and a 1.56 WHIP on the year, the right-hander could be a cost-effective No. 1 starter in DraftKings contests when he travels to pitcher-friendly Turner Field to face a Braves lineup that ranks 26th in the Majors with a .638 OPS against righties. The owner of a lifetime 2.65 ERA and a 1.02 WHIP, Harvey has the skills to quickly turn around his slow start to 2016.

All statistics are accurate through the completion of Wednesday's games.

Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.